Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Wasserturmstraße 3/5, D-91054 Erlangen, Germany; Lehrstuhl für Biochemie, Friedrich-Alexander Universität Erlangen-Nürnberg, Staudtstraße 5, D-91058 Erlangen, Germany.
Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Wasserturmstraße 3/5, D-91054 Erlangen, Germany.
Curr Opin Microbiol. 2017 Feb;35:88-99. doi: 10.1016/j.mib.2017.03.001. Epub 2017 Mar 19.
Nearly all steps of the host cell apoptotic cascade can be subverted by intracellular microorganisms. Some pathogens modulate early steps and interfere with sensing of extracellular signals, cellular stress or signal transduction; others target Bcl-2 proteins, caspases, or inhibitor of apoptosis proteins (IAPs). In many cases the exact molecular mechanisms leading to interference with the host cell apoptotic cascade are still unknown. However, there are some examples where bacterial factors that modulate host cell death have been identified. In this review we will summarize recent findings on how intracellular pathogens or their secreted proteins alter the intrinsic and/or extrinsic host cell apoptotic pathways.
几乎所有宿主细胞凋亡级联的步骤都可能被细胞内微生物颠覆。一些病原体调节早期步骤，并干扰细胞外信号、细胞应激或信号转导的感知；另一些则针对 Bcl-2 蛋白、半胱天冬酶或凋亡抑制蛋白 (IAP)。在许多情况下，导致干扰宿主细胞凋亡级联的确切分子机制尚不清楚。然而，有一些例子表明，调节宿主细胞死亡的细菌因子已经被确定。在这篇综述中，我们将总结最近关于细胞内病原体或其分泌蛋白如何改变宿主细胞内在和/或外在凋亡途径的发现。
