Malhotra Gautam K, Yanala Ujwal, Ravipati Advaitaa, Follet Matthew, Vijayakumar M, Are Chandrakanth
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Johns Hopkins University, Baltimore, Maryland.
J Surg Oncol. 2017 Apr;115(5):564-579. doi: 10.1002/jso.24592. Epub 2017 Mar 20.
Esophageal Cancer (EC) is a lethal malignancy with poor prognosis and significant variations in the incidence, mortality, and histopathology based on geographic regions. The aim of this study was to quantitatively analyze these variations to identify patterns and areas for further research.
We utilized the GLOBOCAN 2012, and Cancer Incidence in five Continents, Volume X (CI5X) database to analyze variations in EC incidence and mortality.
We found the EC incidence and mortality is geographically varied with a particularly high burden in East Asia and Eastern/Southern Africa where esophageal squamous cell carcinoma (SCC) predominates over adenocarcinoma (AC). Interestingly, there is a dichotomy between the high incidence of esophageal SCC in East Africa and low incidence in West Africa. The global incidence and mortality from EC is expected to rise in the coming decades. Asia, and China in particular, will continue to be the areas most burdened by EC, while Africa is expected to surpass the incidence and mortality rates of Europe.
The global burden of EC is expected to rise in the coming years. Understanding the geographic, environmental, and genetic contributors to the development of EC will be essential in combating its prevalence.
食管癌（EC）是一种致命的恶性肿瘤，预后较差，其发病率、死亡率和组织病理学在不同地理区域存在显著差异。本研究的目的是对这些差异进行定量分析，以确定模式和进一步研究的领域。
我们利用全球癌症统计数据2012版（GLOBOCAN 2012）以及《五大洲癌症发病率》第十卷（CI5X）数据库来分析食管癌发病率和死亡率的差异。
我们发现食管癌的发病率和死亡率存在地理差异，东亚以及东部/南部非洲负担尤为沉重，这些地区食管鳞状细胞癌（SCC）的发病率高于腺癌（AC）。有趣的是，东非食管鳞状细胞癌的高发病率与西非的低发病率形成了鲜明对比。预计未来几十年全球食管癌的发病率和死亡率将上升。亚洲，尤其是中国，仍将是食管癌负担最重的地区，而非洲的发病率和死亡率预计将超过欧洲。
预计未来几年全球食管癌负担将上升。了解食管癌发生发展的地理、环境和遗传因素对于应对其流行至关重要。
