Genetics & Developmental Biology Laboratory, School of Biological Sciences & Biotechnology, Indian Institute of Advanced Research/IAR, Koba Institutional Area, Gandhinagar 382 007, Gujarat, India.
Biomed Pharmacother. 2017 May;89:1331-1345. doi: 10.1016/j.biopha.2017.03.001. Epub 2017 Mar 18.
Plants/plant-derived components have been used from ancient times to treat/cure several human diseases. Plants and their parts possess several chemical components that play the vital role in the improvement of human health and their life expectancy. Allopathic medicines have been playing a key role in the treatment of several diseases. Though allopathic medicines provide fast relief, long time consumption cause serious health concerns such as hyperallergic reactions, liver damage, etc. So, the study of medicinal plants which rarely cause any side effect is very important to mankind. Plants contain many health benefit properties like antioxidant, anti-aging, neuroprotective, anti-genotoxic, anti-mutagenic and bioinsecticidal activity. Thus, identification of pharmacological properties of plants/plant-derived components are of utmost importance to be explored. Several model organisms have been used to identify the pharmacological properties of the different plants or active components therein and Drosophila is one of them. Drosophila melanogaster "fruit fly" is a well understood, high-throughput model organism being used more than 110 years to study the different biological aspects related to the development and diseases. Most of the developmental and cell signaling pathways and ∼75% human disease-related genes are conserved between human and Drosophila. Using Drosophila, one can easily analyze the pharmacological properties of plants/plant-derived components by performing several assays available with flies such as survivorship, locomotor, antioxidant, cell death, etc. The current review focuses on the potential of Drosophila melanogaster for the identification of medicinal/pharmacological properties associated with plants/plant-derived components.
植物/植物衍生成分自古以来就被用于治疗/治愈多种人类疾病。植物及其部分拥有多种化学成分，这些成分在改善人类健康和延长寿命方面发挥着至关重要的作用。对抗疗法药物在治疗多种疾病方面一直发挥着关键作用。虽然对抗疗法药物提供了快速缓解，但长期使用会导致严重的健康问题，如过敏反应、肝损伤等。因此，研究很少引起任何副作用的药用植物对人类非常重要。植物含有许多健康益处特性，如抗氧化、抗衰老、神经保护、抗遗传毒性、抗突变和生物杀虫活性。因此，确定植物/植物衍生成分的药理特性非常重要，需要进行探索。已经使用了几种模式生物来鉴定不同植物或其中的活性成分的药理特性，果蝇就是其中之一。黑腹果蝇“果蝇”是一种被广泛理解的高通量模式生物，已经被使用了 110 多年来研究与发育和疾病相关的不同生物学方面。大多数发育和细胞信号通路以及约 75%的与人类疾病相关的基因在人类和果蝇之间是保守的。利用果蝇，可以通过对果蝇进行几种可用的检测，如存活率、运动能力、抗氧化能力、细胞死亡等来轻松分析植物/植物衍生成分的药理特性。本综述重点介绍了黑腹果蝇在鉴定与植物/植物衍生成分相关的药用/药理特性方面的潜力。
