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神经可塑性的分子机制:一个不断扩展的领域

Molecular Mechanisms of Neuroplasticity: An Expanding Universe.

作者信息

Gulyaeva N V

机构信息

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia.

出版信息

Biochemistry (Mosc). 2017 Mar;82(3):237-242. doi: 10.1134/S0006297917030014.

DOI:10.1134/S0006297917030014
PMID:28320264
Abstract

Biochemical processes in synapses and other neuronal compartments underlie neuroplasticity (functional and structural alterations in the brain enabling adaptation to the environment, learning, memory, as well as rehabilitation after brain injury). This basic molecular level of brain plasticity covers numerous specific proteins (enzymes, receptors, structural proteins, etc.) participating in many coordinated and interacting signal and metabolic processes, their modulation forming a molecular basis for brain plasticity. The articles in this issue are focused on different "hot points" in the research area of biochemical mechanisms supporting neuroplasticity.

摘要

突触和其他神经细胞区室中的生化过程是神经可塑性(大脑中的功能和结构改变,使大脑能够适应环境、学习、记忆以及脑损伤后的康复)的基础。大脑可塑性的这一基本分子水平涵盖了众多参与许多协调和相互作用的信号及代谢过程的特定蛋白质(酶、受体、结构蛋白等),它们的调节形成了大脑可塑性的分子基础。本期的文章聚焦于支持神经可塑性的生化机制研究领域的不同“热点”。

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1
Molecular Mechanisms of Neuroplasticity: An Expanding Universe.神经可塑性的分子机制:一个不断扩展的领域
Biochemistry (Mosc). 2017 Mar;82(3):237-242. doi: 10.1134/S0006297917030014.
2
Learning in the fast lane: new insights into neuroplasticity.快速通道中的学习:神经可塑性的新见解。
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Is being plastic fantastic? Mechanisms of altered plasticity after developmental traumatic brain injury.可塑性是奇妙的吗?发育性创伤性脑损伤后可塑性改变的机制。
Dev Neurosci. 2006;28(4-5):364-79. doi: 10.1159/000094163.
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Cellular and molecular neuronal plasticity.细胞与分子层面的神经元可塑性
Handb Clin Neurol. 2015;128:681-90. doi: 10.1016/B978-0-444-63521-1.00042-X.
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[Neurobiology of learning--the basis of an alteration process].[学习的神经生物学——一种改变过程的基础]
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[Theoretical and clinical significance of neuroplasticity].[神经可塑性的理论与临床意义]
Bratisl Lek Listy. 1997 Dec;98(12):667-73.
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[A functional role for PDZ proteins in synapse organization and synaptic plasticity].PDZ蛋白在突触组织和突触可塑性中的功能作用
Tanpakushitsu Kakusan Koso. 1998 Aug;43(10):1355-64.
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Neuroplasticity as a function of second language learning: anatomical changes in the human brain.作为第二语言学习功能的神经可塑性:人类大脑的解剖学变化。
Cortex. 2014 Sep;58:301-24. doi: 10.1016/j.cortex.2014.05.001. Epub 2014 May 17.
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Role of Atypical Protein Kinases in Maintenance of Long-Term Memory and Synaptic Plasticity.非典型蛋白激酶在长期记忆维持和突触可塑性中的作用。
Biochemistry (Mosc). 2017 Mar;82(3):243-256. doi: 10.1134/S0006297917030026.
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Glutamate receptor plasticity at excitatory synapses in the brain.大脑中兴奋性突触处的谷氨酸受体可塑性。
Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1058-63. doi: 10.1111/j.1440-1681.2007.04722.x.

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Advances in hemiplegia rehabilitation: modern therapeutic interventions to enhance activities of daily living.偏瘫康复的进展:增强日常生活活动能力的现代治疗干预措施。
Front Neurol. 2025 Mar 28;16:1555990. doi: 10.3389/fneur.2025.1555990. eCollection 2025.
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Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.
改善神经康复的物理治疗干预和神经调节技术的最新趋势。
CNS Neurol Disord Drug Targets. 2025;24(7):521-545. doi: 10.2174/0118715273341882250114054733.
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Postoperative evaluation of visual and cognitive functions following cataract surgery in patients with age-related cataracts: a prospective longitudinal study.年龄相关性白内障患者白内障手术后视觉和认知功能的术后评估:一项前瞻性纵向研究。
Front Neurosci. 2025 Jan 3;18:1505585. doi: 10.3389/fnins.2024.1505585. eCollection 2024.
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Neurodevelopmental benefits of judo training in preschool children: a multinational, mixed methods follow-up study.柔道训练对学龄前儿童神经发育的益处:一项跨国、混合方法的随访研究。
Front Psychol. 2024 Dec 18;15:1457515. doi: 10.3389/fpsyg.2024.1457515. eCollection 2024.
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Epigenetic Modifications and Neuroplasticity in the Pathogenesis of Depression: A Focus on Early Life Stress.抑郁症发病机制中的表观遗传修饰与神经可塑性:聚焦早期生活应激
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