Rozov A V, Valiullina F F, Bolshakov A P
Kazan Federal University, OpenLab of Neurobiology, Kazan, 420008, Russia.
Biochemistry (Mosc). 2017 Mar;82(3):257-263. doi: 10.1134/S0006297917030038.
Long-term potentiation and depression of synaptic transmission have been considered as cellular mechanisms of memory in studies conducted in recent decades. These studies were predominantly focused on mechanisms underlying plasticity at excitatory synapses. Nevertheless, normal central nervous system functioning requires maintenance of a balance between inhibition and excitation, suggesting existence of similar modulation of glutamatergic and GABAergic synapses. Here we review the involvement of G-protein-coupled receptors in the generation of long-term changes in synaptic transmission of inhibitory synapses. We considered the role of endocannabinoid and glutamate systems, GABA and opioid receptors in the induction of long-term potentiation and long-term depression in inhibitory synapses. The pre- and postsynaptic effects of activation of these receptors are also discussed.
在近几十年开展的研究中，突触传递的长时程增强和抑制被视为记忆的细胞机制。这些研究主要聚焦于兴奋性突触可塑性的潜在机制。然而，正常的中枢神经系统功能需要维持抑制和兴奋之间的平衡，这表明谷氨酸能和γ-氨基丁酸能突触存在类似的调节。在此，我们综述了G蛋白偶联受体在抑制性突触传递长期变化产生过程中的作用。我们探讨了内源性大麻素和谷氨酸系统、γ-氨基丁酸和阿片受体在抑制性突触长时程增强和长时程抑制诱导中的作用。还讨论了这些受体激活的突触前和突触后效应。
