启动！IQGAP1对信号通路的控制。
And Akt-ion! IQGAP1 in control of signaling pathways.
作者信息
Choi Suyong, Anderson Richard A
机构信息
School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
EMBO J. 2017 Apr 13;36(8):967-969. doi: 10.15252/embj.201796827. Epub 2017 Mar 20.
Abstract
ERK signaling and Akt signaling are inversely correlated in some cancers. Yet, the precise molecular mechanism for cross‐inhibition remains unclear. In this issue of , Pan (2017) show that when Akt is on, its phosphorylated cytoplasmic substrate FOXO1 turns off ERK activity by reshaping the Ras‐ERK scaffold IQGAP1.
摘要
在某些癌症中，细胞外信号调节激酶（ERK）信号传导和蛋白激酶B（Akt）信号传导呈负相关。然而，交叉抑制的确切分子机制仍不清楚。在本期杂志中，潘（2017年）表明，当Akt激活时，其磷酸化的细胞质底物叉头框蛋白O1（FOXO1）通过重塑Ras-ERK支架IQGAP1来关闭ERK活性。
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