Center for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455.
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1):a029116. doi: 10.1101/cshperspect.a029116.
The memory B-cell pool in an immune individual is more heterogeneous than previously recognized. The different types of memory B cells likely play distinct roles in tuning the secondary immune response because they differ in their potential to generate plasmablasts, which secrete antibodies, or germinal center (GC) cells, which generate new and higher affinity memory cells. We propose that the production of plasmablasts or GC cells by a memory B cell is controlled by its state of differentiation and the amount and affinity of antigen-specific antibodies present in the individual in which it resides.
在免疫个体中，记忆 B 细胞池比以前认识的更加多样化。不同类型的记忆 B 细胞可能在调节二次免疫反应中发挥不同的作用，因为它们在产生浆母细胞（分泌抗体）或生发中心（GC）细胞（产生新的和更高亲和力的记忆细胞）的潜力上存在差异。我们提出，记忆 B 细胞产生浆母细胞或 GC 细胞的能力受其分化状态以及存在于其所在个体中的抗原特异性抗体的数量和亲和力的控制。
