Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1):a029405. doi: 10.1101/cshperspect.a029405.
Memory is the defining feature of the adaptive immune system. Humoral immune memory is largely though not exclusively generated in the germinal center (GC), which spawns long-lived plasma cells that support ongoing serum antibody titers as well as "memory B cells" (MBCs) that persist in the immune host at expanded frequencies. Upon reencounter with antigen, these MBCs are reactivated and potentially can contribute to protection by further expansion, rapid differentiation to antibody-forming cells, and/or reseeding of a new round of GCs along with somatic V region mutation and selection. Here I will discuss what controls these various potential fates of MBCs and the functional significance of different types of MBC reactivation.
记忆是适应性免疫系统的决定性特征。体液免疫记忆主要（但并非完全）在生发中心（GC）中产生，生发中心产生长寿浆细胞，支持持续的血清抗体滴度，以及“记忆 B 细胞”（MBC）以扩大的频率在免疫宿主中持续存在。再次遇到抗原时，这些 MBC 被激活，并且可以通过进一步扩增、快速分化为产生抗体的细胞以及/或与体细胞 V 区突变和选择一起重新启动新一轮 GC 来为保护做出贡献。在这里，我将讨论是什么控制了 MBC 的这些各种潜在命运，以及不同类型的 MBC 激活的功能意义。
