Kallenbach J M, Panz V R, Joffe B I, Jankelow D, Anderson R, Haitas B, Seftel H C
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Chest. 1988 Apr;93(4):751-7. doi: 10.1378/chest.93.4.751.
The mechanism of early morning bronchospasm in asthma was investigated by analyzing circadian variations in the plasma levels of cortisol, ACTH, epinephrine, and norepinephrine, as well as in the serum neutrophil chemotactic activity and heart rate in asthmatic patients with (n = 6) and without (n = 7) "morning dipping" and normal subjects. Findings suggested that an exaggerated nocturnal nadir in plasma cortisol levels may precipitate "morning dipping" in some patients with asthma.
通过分析哮喘患者（n = 6）和非哮喘患者（n = 7）以及正常受试者血浆皮质醇、促肾上腺皮质激素、肾上腺素和去甲肾上腺素水平的昼夜变化，以及血清中性粒细胞趋化活性和心率的昼夜变化，研究了哮喘患者清晨支气管痉挛的机制。研究结果表明，部分哮喘患者血浆皮质醇水平夜间最低点过度降低可能会引发“晨降”现象。
