Allgayer H, Kruis W, Paumgartner G, Wiebecke B, Brown L, Erdmann E
Department of Internal Medicine I, Klinikum Grosshadern, München, F.R.G.
Dig Dis Sci. 1988 Apr;33(4):417-22. doi: 10.1007/BF01536025.
In inflammatory bowel disease (IBD), mucosal damage and loss of colonic function are regarded as major consequences of inflammation. Decreased colonic (Na+ + K+)-ATPase activities with diminished reabsorption of sodium and water have been found in active stages of ulcerative colitis. In this study, we report an inverse relationship between colonic (Na+ + K+)-ATPase activity and the degree of mucosal inflammation in 19 patients with IBD of mild to moderate disease activity. Various macroscopic and histologic types of mucosal lesions were differently associated with the (Na+ + K+)-ATPase activities. 5'-nucleotidase activity was not associated with the degree of mucosal inflammation or the kind of macroscopic or histologic lesions. Our findings support the view that, in contrast to 5H-nucleotidase, (Na+ + K+)-ATPase activity may better reflect the severity of mucosal damage and the degree of inflammation in IBD.
在炎症性肠病（IBD）中，黏膜损伤和结肠功能丧失被视为炎症的主要后果。在溃疡性结肠炎的活动期，已发现结肠（Na⁺ + K⁺）-ATP酶活性降低，钠和水的重吸收减少。在本研究中，我们报告了19例轻度至中度疾病活动度的IBD患者中，结肠（Na⁺ + K⁺）-ATP酶活性与黏膜炎症程度之间呈负相关。各种宏观和组织学类型的黏膜病变与（Na⁺ + K⁺）-ATP酶活性的相关性各不相同。5'-核苷酸酶活性与黏膜炎症程度或宏观或组织学病变类型无关。我们的研究结果支持这样一种观点，即与5'-核苷酸酶不同，（Na⁺ + K⁺）-ATP酶活性可能更好地反映IBD中黏膜损伤的严重程度和炎症程度。
