Rachmilewitz D, Karmeli F, Sharon P
Isr J Med Sci. 1984 Aug;20(8):681-4.
Na-K-ATPase has an important role in intestinal sodium and fluid absorption. We tested the colonic activity of this enzyme in patients with active ulcerative colitis to elucidate its role in the pathogenesis of the diarrhea associated with this disease. Colonic Na-K-ATPase activity in 13 patients with active ulcerative colitis prior to therapy was one-fourth of its activity in 14 normal subjects: 0.68 +/- 0.13 (SE) and 2.60 +/- 0.45 mumol/h . mg protein, respectively. In six patients with active ulcerative colitis on steroid therapy, the enzyme activity was similar to that observed in normal subjects. These results indicate an inhibition of colonic Na-K-ATPase activity in active ulcerative colitis, which may contribute to intestinal fluid accumulation and thus to the diarrhea in this disease.
钠钾ATP酶在肠道钠和液体吸收中起重要作用。我们检测了活动期溃疡性结肠炎患者该酶的结肠活性，以阐明其在与该疾病相关的腹泻发病机制中的作用。13例活动期溃疡性结肠炎患者治疗前的结肠钠钾ATP酶活性是14例正常受试者的四分之一，分别为0.68±0.13（标准误）和2.60±0.45微摩尔/小时·毫克蛋白。6例接受类固醇治疗的活动期溃疡性结肠炎患者，其酶活性与正常受试者相似。这些结果表明活动期溃疡性结肠炎患者的结肠钠钾ATP酶活性受到抑制，这可能导致肠道液体蓄积，进而导致该疾病的腹泻。
