Noorduyn L A, Herman C J
Department of Pathology, Stichting Samenwerking Delftse Ziekenhuizen Delft, The Netherlands.
Eur J Cancer Clin Oncol. 1987 Feb;23(2):157-62. doi: 10.1016/0277-5379(87)90009-5.
Mixed mesodermal tumor of the ovary is a rare neoplasm. The diagnosis is made if an ovarian carcinoma contains heterologous sarcomatous differentiation. With the help of an immunopathologic stain for desmin, the intermediate filament protein of muscle cells, twenty cases of ovarian adenocarcinoma were examined for the presence of morphologically unrecognizable heterologous tumor cells. Six of twenty tumors were positive. There was no significant correlation between a number of clinical parameters and desmin positivity. The authors conclude that mixed mesodermal tumor of the ovary may not be a separate entity. Instead, there may be a single group of ovarian epithelial tumors ranging from borderline or well-differentiated carcinomas to poorly-differentiated tumors which may show homologous (carcinosarcoma) or heterologous (mixed mesodermal tumor) differentiation.
卵巢混合性中胚层肿瘤是一种罕见的肿瘤。如果卵巢癌含有异源性肉瘤样分化，则可做出该诊断。借助针对结蛋白（一种肌肉细胞的中间丝蛋白）的免疫病理染色，对20例卵巢腺癌进行检查，以寻找形态上无法识别的异源性肿瘤细胞。20个肿瘤中有6个呈阳性。一些临床参数与结蛋白阳性之间无显著相关性。作者得出结论，卵巢混合性中胚层肿瘤可能不是一个独立的实体。相反，可能存在一组单一的卵巢上皮性肿瘤，范围从交界性或高分化癌到低分化肿瘤，后者可能表现出同源性（癌肉瘤）或异源性（混合性中胚层肿瘤）分化。
