Center for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital, Bologna, Italy.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Sci Rep. 2017 Mar 21;7:44685. doi: 10.1038/srep44685.
Complementary and alternative medicine (CAM) is the term used to describe many kinds of products, practices, and systems that are not part of conventional medicine. Cancer patients usually do everything they can to combat the disease, manage its symptoms, and cope with the side effects of treatment. Unfortunately, patients who use CAM underestimate the risk of interaction with cancer therapy or worse they omit conventional therapy thus reducing the possibility of cancer remission. Herein we analyzed the effects of Vidatox 30 CH (venom extracted from the Junceus Rhopalurus scorpion) on hepatocellular carcinoma (HCC), the second leading cause of cancer-related deaths. We found out that Vidatox increases HCC proliferation and invasion whereas it does not seem to interact with sorafenib, the orally active multikinase inhibitor approved for the treatment of advanced hepatocellular carcinoma. Our results suggest that the concentration of Vidatox used in the present study has not anti-neoplastic effects and care must be taken in hiring Vidatox in patients with HCC.
补充和替代医学（CAM）是指描述许多不属于常规医学的产品、实践和系统的术语。癌症患者通常会竭尽全力对抗疾病、控制其症状并应对治疗的副作用。不幸的是，使用 CAM 的患者低估了与癌症治疗相互作用的风险，或者更糟糕的是，他们忽略了常规治疗，从而降低了癌症缓解的可能性。在此，我们分析了 Vidatox 30 CH（从 Junceus Rhopalurus 蝎子中提取的毒液）对肝细胞癌（HCC）的影响，这是癌症相关死亡的第二大主要原因。我们发现 Vidatox 可增加 HCC 的增殖和侵袭，而似乎与sorafenib（一种用于治疗晚期肝细胞癌的口服多激酶抑制剂）没有相互作用。我们的研究结果表明，在本研究中使用的 Vidatox 浓度没有抗肿瘤作用，在 HCC 患者中使用 Vidatox 时必须谨慎。
