Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Mol Psychiatry. 2017 Dec;22(12):1659-1663. doi: 10.1038/mp.2017.29. Epub 2017 Mar 21.
The National Institute of Mental Health (NIMH) has made sustained investments in the development of genomic resources over the last two decades. These investments have led to the development of the largest biorepository for psychiatric genetics as a centralized national resource. In the realm of genomic resources, NIMH has been supporting large team science (TS) consortia focused on gene discovery, fine mapping of loci, and functional genomics using state-of-the-art technologies. The scientific output from these efforts has not only begun to transform our understanding of the genetic architecture of neuropsychiatric disorders, but it has also led to a broader cultural change among the investigator community towards deeper collaborations and broad pre-publication sharing of data and resources. The NIMH supported efforts have led to a vast increase in the amount of genetic and genomic resources available to the mental health research community. Here we provide an account of the existing resources and estimates of the scale and scope of what will be available in the near future. All biosamples and data described are intended for broad sharing with researchers worldwide, as allowed by the subject consent and applicable laws.
美国国立精神卫生研究所（NIMH）在过去的二十年中一直对基因组资源的开发进行持续投资。这些投资促成了最大的精神疾病遗传学生物样本库的发展，使其成为一个集中的国家资源。在基因组资源方面，NIMH 一直支持大型团队科学（TS）联盟，专注于使用最先进技术进行基因发现、基因座精细定位和功能基因组学研究。这些努力的科学成果不仅开始改变我们对神经精神疾病遗传结构的理解，而且还促使研究人员社区发生了更广泛的文化变革，即朝着更深入的合作以及广泛的预发表数据和资源共享方向发展。NIMH 支持的工作导致了精神健康研究界可用的遗传和基因组资源数量的大量增加。在这里，我们提供了现有资源的说明，并对近期内可用资源的规模和范围进行了估计。根据主题同意书和适用法律，所描述的所有生物样本和数据都旨在与全球研究人员广泛共享。
