Bakkal Meltem, Abbasoglu Zerrin, Kargul Betul
Oral Health Prev Dent. 2017;15(2):163-167. doi: 10.3290/j.ohpd.a37928.
To evaluate the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) application on noncarious MIH (molar-incisor hypomineralisation) lesions using a DIAGNOdent device (KaVo), which measures laser fluorescence within the mineral structure of the tooth.
A total of 461 subjects age 7-12 (mean ± SD was 9.9 ± 1.6) years were examined. Fifty- four children were diagnosed with MIH and divided into 2 groups. A total of 38 teeth met the inclusion criteria and were included in the study. Group 1 subjects (n = 15) used a paste containing 10% CPP-ACP, and group 2 subjects (n = 23) used a paste containing 10% CPP-ACP with 0.2% NaF (CPP-ACFP) for one month.
After the application of the pastes for one month, significant decreases were found in the mean DIAGNOdent readings for both groups (CPP-ACP p = 0.0015 and CPP-ACFP p = 0.0001). However, the percentage decreases in both groups were not significantly different from each other (60.4% and 45.5% in CPP-ACP and CPP-ACFP groups, respectively).
This pilot study shows that using CPP-ACP and CPP-ACFP had a positive effect in reducing hypomineralisation on enamel surfaces of MIH-diagnosed teeth for a one month period. It is important to diagnose molar-incisor hypomineralisation at an early stage to prevent excessive caries develeopment. Therefore, further clinical studies are necessary on the long-term application of these kinds of nanocomplexes.
使用DIAGNOdent设备（卡瓦）评估酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）和酪蛋白磷酸肽-无定形氟化磷酸钙（CPP-ACFP）对非龋性磨牙-切牙低矿化（MIH）病变的影响，该设备可测量牙齿矿化结构内的激光荧光。
共检查了461名7至12岁（平均±标准差为9.9±1.6）的受试者。54名儿童被诊断为MIH并分为2组。共有38颗牙齿符合纳入标准并被纳入研究。第1组受试者（n = 15）使用含10% CPP-ACP的糊剂，第2组受试者（n = 23）使用含10% CPP-ACP和0.2% NaF的糊剂（CPP-ACFP），为期1个月。
使用糊剂1个月后，两组的平均DIAGNOdent读数均显著下降（CPP-ACP组p = 0.0015，CPP-ACFP组p = 0.0001）。然而，两组的下降百分比彼此之间无显著差异（CPP-ACP组和CPP-ACFP组分别为60.4%和45.5%）。
这项初步研究表明，使用CPP-ACP和CPP-ACFP在降低MIH诊断牙齿釉质表面低矿化方面有积极作用，为期1个月。早期诊断磨牙-切牙低矿化对于预防龋齿过度发展很重要。因此，有必要对这类纳米复合物的长期应用进行进一步的临床研究。
