Mei Yang, Mu Yang, Wang Win, Tan Bo-Tao, Chen Yao-Hua, Li Yu-Ping, Zhu Dan, Li Wei, Cui Jian, Yu Le-Hua
Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Department of Pain Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, People's Republic of China.
J Pain Res. 2022 Oct 21;15:3319-3326. doi: 10.2147/JPR.S385913. eCollection 2022.
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) can influence energy metabolism. Energy metabolism imbalance is closely associated with the occurrence of neuropathic pain (NeP). Rs10789038 and rs2796498 are genetic polymorphisms of , the gene encoding AMPK, which is closely related to energy metabolism imbalance. This study aimed to explore the relationship between and postherpetic neuralgia (PHN) in the southwestern Chinese Han population.
This study enrolled 132 PHN patients and 118 healthy subjects. The rs10789038 and rs2796498 genotypes were identified in all participants. The association between these single nucleotide polymorphisms and PHN susceptibility was evaluated in the dominant and recessive models. Haplotype analysis of patients with PHN and healthy controls was performed.
The PHN patients were older than the healthy subjects ( < 0.05); however, the other clinical characteristics between two groups were not significantly different (all >0.05). Genotypes and allele frequencies differed significantly between PHN patients and healthy subjects in the rs10789038 polymorphism ( < 0.05), but not in rs2796498 ( > 0.05). In addition, the GG haplotype of rs10789038-rs2796498 correlated negatively with PHN occurrence in haplotype analysis ( < 0.05).
PHN occurrence may be related to the rs10789038 A>G genetic polymorphism in the southwestern Chinese Han population.
5'-单磷酸腺苷（AMP）激活的蛋白激酶（AMPK）可影响能量代谢。能量代谢失衡与神经性疼痛（NeP）的发生密切相关。Rs10789038和rs2796498是编码AMPK的基因的基因多态性，该基因与能量代谢失衡密切相关。本研究旨在探讨中国西南汉族人群中该基因与带状疱疹后神经痛（PHN）之间的关系。
本研究纳入了132例PHN患者和118名健康受试者。对所有参与者进行了rs10789038和rs2796498基因分型。在显性和隐性模型中评估这些单核苷酸多态性与PHN易感性之间的关联。对PHN患者和健康对照进行单倍型分析。
PHN患者的年龄大于健康受试者（P<0.05）；然而，两组之间的其他临床特征无显著差异（均P>0.05）。在rs10789038多态性中，PHN患者和健康受试者的基因型和等位基因频率存在显著差异（P<0.05），但在rs2796498中无显著差异（P>0.05）。此外，在单倍型分析中，rs10789038-rs2796498的GG单倍型与PHN的发生呈负相关（P<0.05）。
在中国西南汉族人群中，PHN的发生可能与rs10789038 A>G基因多态性有关。
