印度尼西亚日惹新诊断2型糖尿病患者的变异情况及临床特征
variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia.
作者信息
Virginia Dita Maria, Wahyuningsih Mae Sri Hartati, Nugrahaningsih Dwi Aris Agung
机构信息
Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 552181, Indonesia.
出版信息
Asian Biomed (Res Rev News). 2021 Aug 20;15(4):161-170. doi: 10.2478/abm-2021-0021. eCollection 2021 Aug.
BACKGROUND
Adenosine monophosphate (AMP)-activated protein kinase (AMPK; EC 2.7.11.31) enzymes play a pivotal role in cell metabolism. They are involved in type 2 diabetes mellitus (T2DM) pathogenesis. Genetic variation of coding for the AMPK α2 catalytic subunit (AMPKα2) is reported to be associated with susceptibility for T2DM.
OBJECTIVES
To determine the association between genetic variations (rs2796498, rs9803799, and rs2746342) with clinical characteristics in patients newly diagnosed with T2DM.
METHODS
We performed a cross-sectional study including 166 T2DM patients from 10 primary health care centers in Yogyakarta, Indonesia. We measured fasting plasma glucose, hemoglobin A1c, serum creatinine, glomerular filtration rate, blood pressure, and body mass index as clinical characteristics. genetic variations were determined by TaqMan SNP genotyping assay. Hardy-Weinberg equilibrium was calculated using χ tests.
RESULTS
There was no difference in clinical characteristics for genotypes rs2796498, rs9803799, or rs2746342 ( > 0.05). No significant association was found between genetic variations and any clinical feature observed. Further subgroup analysis adjusting for age, sex, and waist circumference did not detect any significant association of genetic variations with clinical characteristics ( > 0.05).
CONCLUSION
genetic variation is not associated with the clinical characteristics of Indonesian patients with newly diagnosed T2DM.
背景
单磷酸腺苷（AMP）激活的蛋白激酶（AMPK；EC 2.7.11.31）酶在细胞代谢中起关键作用。它们参与2型糖尿病（T2DM）的发病机制。据报道，编码AMPKα2催化亚基（AMPKα2）的基因变异与T2DM易感性相关。
目的
确定基因变异（rs2796498、rs9803799和rs2746342）与新诊断T2DM患者临床特征之间的关联。
方法
我们进行了一项横断面研究，纳入了来自印度尼西亚日惹10个初级卫生保健中心的166例T2DM患者。我们测量了空腹血糖、糖化血红蛋白、血清肌酐、肾小球滤过率、血压和体重指数作为临床特征。通过TaqMan SNP基因分型检测确定基因变异。使用χ检验计算哈迪-温伯格平衡。
结果
rs2796498、rs9803799或rs2746342基因型的临床特征无差异（P>0.05）。未发现基因变异与观察到的任何临床特征之间存在显著关联。进一步根据年龄、性别和腰围进行亚组分析，未发现基因变异与临床特征有任何显著关联（P>0.05）。
结论
基因变异与新诊断的印度尼西亚T2DM患者的临床特征无关。
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