Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU Langone Medical Center, School of Medicine, New York University, New York, NY, USA.
Lake Erie College of Osteopathic Medicine, Pennsylvania, PA, USA.
Mult Scler. 2018 Apr;24(4):512-519. doi: 10.1177/1352458517701588. Epub 2017 Mar 21.
Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible.
The goal of this study was to measure the sensitivity of two cognitive assessment approaches that are brief, repeatable, and suitable for clinical practice and for multicenter investigation.
Participants with POMS ( n = 69) were consecutively evaluated as part of outpatient neurologic visits and compared to healthy control participants (HC, n = 66) using the Brief International Cognitive Assessment for MS (BICAMS) approach and timed information processing measures from Cogstate, a computer-based assessment.
There was strong agreement in the detection rate of impairment between both assessments, with 26% for the BICAMS and 27% for Cogstate. Two of the Cogstate tasks were the most sensitive individual measures.
Both the BICAMS and Cogstate timed processing measures offer practical, sensitive, and standardized approaches for cognitive screening assessment in POMS.
认知障碍是儿科发病多发性硬化症（POMS）的一个常见且令人困扰的特征。在门诊环境中进行简短的认知评估可以识别和纵向监测认知障碍，以便进行早期干预。
本研究的目的是测量两种认知评估方法的敏感性，这两种方法都简短、可重复，适用于临床实践和多中心研究。
作为门诊神经就诊的一部分，连续评估患有 POMS 的参与者（n=69），并将其与健康对照组参与者（HC，n=66）进行比较，使用简短国际多发性硬化症认知评估（BICAMS）方法和 Cogstate 的计时信息处理测量，Cogstate 是一种基于计算机的评估。
两种评估方法在检测障碍的检出率方面具有很强的一致性，BICAMS 为 26%，Cogstate 为 27%。Cogstate 的两项任务是最敏感的个体测量。
BICAMS 和 Cogstate 计时处理测量都为 POMS 的认知筛查评估提供了实用、敏感和标准化的方法。
