Gao Yunliang, Lin Le, Li Tao, Yang Jinrui, Wei Yongbao
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, United States.
Department of Urology, Fujian Medical University Teaching Hospital, Fujian Provincial Hospital, Fuzhou 350001, PR China.
Gene. 2017 Jun 15;616:1-7. doi: 10.1016/j.gene.2017.03.021. Epub 2017 Mar 18.
MicroRNAs (miRNAs) constitute a large family of small, non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. miRNAs appear to hold promise of mechanistic explanations for various physiological and pathological processes. miRNA-223 is highly conserved and preferentially expressed in the hematopoietic system in regulation of myeloid differentiation. Recently, increasing evidence suggests that miRNA-223 may also play an essential part in both hematological malignancies and solid tumors. miRNA-223 can function as either an oncogene or a tumor suppressor gene, which is achieved by targeting a wide range of genes and regulating downstream signal transduction. As yet, the function of miR-223 in cancer has not been fully characterized and understood. To make it more clear, this review firstly summarizes the present understanding of the regulation of miR-223 at the molecular level, its crucial role in oncogenesis, development, and metastasis, its function as a diagnostic and prognostic biomarker and finally, its potential applications in monitoring and therapy of diverse types of malignancies.
微小RNA（miRNA）构成了一个庞大的小非编码RNA家族，具有在转录后调节基因表达的能力。miRNA似乎有望为各种生理和病理过程提供机制解释。miRNA-223高度保守，在造血系统中优先表达，参与髓系分化的调控。最近，越来越多的证据表明，miRNA-223在血液系统恶性肿瘤和实体瘤中也可能发挥重要作用。miRNA-223既可以作为癌基因，也可以作为肿瘤抑制基因发挥作用，这是通过靶向多种基因并调节下游信号转导来实现的。迄今为止，miR-223在癌症中的功能尚未得到充分表征和理解。为了更清楚地说明这一点，本综述首先总结了目前在分子水平上对miR-223调控的理解、其在肿瘤发生、发展和转移中的关键作用、其作为诊断和预后生物标志物的功能，以及最后其在各种恶性肿瘤监测和治疗中的潜在应用。
