重组B细胞刺激因子2（BSF-2）无抗病毒活性。
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2).
作者信息
Hirano T, Matsuda T, Hosoi K, Okano A, Matsui H, Kishimoto T
机构信息
Institute for Molecular and Cellular Biology, Osaka University, Japan.
出版信息
Immunol Lett. 1988 Jan;17(1):41-5. doi: 10.1016/0165-2478(88)90099-5.
Recombinant B cell stimulatory factor 2 (rBSF-2) did not display any detectable level of antiviral activity when using human diploid fibroblasts, DIP-2, FS-4, FS-7, amnion-derived WISH and FL cells with vesicular stomatitis virus (VSV) and Sindbis virus as challenging agents (less than 2.5 X 10(2) IU/mg). Furthermore anti-IFN-beta could not neutralize the immunoglobulin-inducing activity of BSF-2. Moreover anti-BSF-2 could not neutralize the antiviral activity of IFN-beta. The data indicate that BSF-2 is functionally and immunologically not related to IFNs.
当使用人二倍体成纤维细胞、DIP - 2、FS - 4、FS - 7、羊膜来源的WISH和FL细胞，并以水疱性口炎病毒（VSV）和辛德毕斯病毒作为攻击因子时，重组B细胞刺激因子2（rBSF - 2）未显示出任何可检测到的抗病毒活性水平（低于2.5×10² IU/mg）。此外，抗IFN - β不能中和BSF - 2的免疫球蛋白诱导活性。而且，抗BSF - 2不能中和IFN - β的抗病毒活性。这些数据表明，BSF - 2在功能和免疫方面与干扰素无关。
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