Wang Gang, Wang Jun-Jie, Guan Rui, Du Li, Gao Jing, Fu Xing-Li
a Department of Pharmaceutics , Jiangsu University , Shanghai , China.
b Hubei University of Medicine , Shiyan , China.
Nutr Cancer. 2017 May-Jun;69(4):534-554. doi: 10.1080/01635581.2017.1295090. Epub 2017 Mar 21.
The imbalance between glucose metabolism and cancer cell growth in tumor microenvironment (TME), which are closely related with the occurrence and progression of cancer. Accumulating evidence has demonstrated that flavonoids exert many biological properties, including antioxidant and anticarcinogenic activities. Recently, the roles and applications of flavonoids, particularly in relation to glucose metabolism in cancers, have been highlighted. Thus, the identification of flavonoids targeting alternative glucose metabolism pathways in TME may represent an attractive approach to the more effective therapeutic strategies for cancer. In this review, we will focus on the roles of flavonoids in regulating glucose metabolism and cancer cell growth in TME, such as proliferation advantage, cell mobility, and chemoresistance to cancer, as well as modifiers of thermal sensitivity. Not only have such large-scale endeavors been useful in providing fundamental insights into natural and synthesized flavonoids that can prevent and treat cancer, but also have led to the discovery of potential targets for cancer therapy.
肿瘤微环境（TME）中葡萄糖代谢与癌细胞生长之间的失衡，这与癌症的发生和发展密切相关。越来越多的证据表明，黄酮类化合物具有多种生物学特性，包括抗氧化和抗癌活性。最近，黄酮类化合物的作用和应用，特别是与癌症中葡萄糖代谢的关系，受到了关注。因此，鉴定靶向TME中替代葡萄糖代谢途径的黄酮类化合物，可能是一种更有效的癌症治疗策略的有吸引力的方法。在这篇综述中，我们将关注黄酮类化合物在调节TME中葡萄糖代谢和癌细胞生长方面的作用，如增殖优势、细胞迁移以及对癌症的化疗耐药性，以及热敏感性调节剂。这些大规模的研究不仅有助于深入了解可预防和治疗癌症的天然和合成黄酮类化合物，还导致了癌症治疗潜在靶点的发现。
