Anderson Christopher W, Boardman Nicole, Luo Jiesi, Park Jinkyu, Qyang Yibing
Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, 06510, USA.
Molecular Cell Genetics and Developmental Biology Program, Yale University, New Haven, CT, 06510, USA.
Curr Cardiol Rep. 2017 Apr;19(4):34. doi: 10.1007/s11886-017-0841-2.
The purpose of this review is to provide a broad overview of current trends in stem cell research and its applications in cardiovascular medicine. Researches on different stem cell sources, their inherent characteristics, and the limitations they have in medical applications are discussed. Additionally, uses of stem cells for both modeling and treating cardiovascular disease are discussed, taking note of the obstacles these engineered interventions must overcome to be clinically viable.
Tissue engineering aims to replace dysfunctional tissues with engineered constructs. Stem cell technologies have been a great enabling factor in working toward this goal. Many tissue-engineered products are in development that utilize stem cell technology. Although promising, some refinement must be made to these constructs with respect to safety and functionality. A deeper understanding of basic differentiation and tissue developmental mechanisms is required to allow these engineered tissues to be translated into the clinic.
本综述旨在全面概述干细胞研究的当前趋势及其在心血管医学中的应用。讨论了不同干细胞来源的研究、它们的固有特性以及在医学应用中的局限性。此外，还讨论了干细胞在心血管疾病建模和治疗中的应用，并注意到这些工程干预措施在临床上可行必须克服的障碍。
组织工程旨在用工程构建体替代功能失调的组织。干细胞技术一直是实现这一目标的重要推动因素。许多利用干细胞技术的组织工程产品正在研发中。尽管前景广阔，但这些构建体在安全性和功能性方面仍需进一步改进。需要更深入地了解基本分化和组织发育机制，以使这些工程组织能够应用于临床。
