Harris Maria H, Rifas-Shiman Sheryl L, Calafat Antonia M, Ye Xiaoyun, Mora Ana Maria, Webster Thomas F, Oken Emily, Sagiv Sharon K
Center for Environmental Research and Children's Health, University of California, Berkeley School of Public Health , Berkeley, California, United States.
Division of Epidemiology, University of California, Berkeley School of Public Health , Berkeley, California, United States.
Environ Sci Technol. 2017 May 2;51(9):5193-5204. doi: 10.1021/acs.est.6b05811. Epub 2017 Apr 11.
Certain per- and polyfluoroalkyl substances (PFASs) are suspected developmental toxicants, but data on PFAS concentrations and exposure routes in children are limited. We measured plasma PFASs in children aged 6-10 years from the Boston-area Project Viva prebirth cohort, and used multivariable linear regression to estimate associations with sociodemographic, behavioral, and health-related factors, and maternal PFASs measured during pregnancy. PFAS concentrations in Project Viva children (sampled 2007-2010) were similar to concentrations among youth participants (aged 12-19 years) in the 2007-8 and 2009-10 National Health and Nutrition Examination Survey (NHANES); mean concentrations of most PFASs declined from 2007 to 2010 in Project Viva and NHANES. In mutually adjusted models, predictors of higher PFAS concentrations included older child age, lower adiposity, carpeting or a rug in the child's bedroom, higher maternal education, and higher neighborhood income. Concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexanesulfonate (PFHxS), and 2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH) were 26-36% lower in children of black mothers compared to children of white mothers and increased 12-21% per interquartile range increase in maternal pregnancy PFASs. Breastfeeding duration did not predict childhood PFAS concentrations in adjusted multivariable models. Together, the studied predictors explained the observed variability in PFAS concentrations to only a modest degree.
某些全氟和多氟烷基物质（PFASs）被怀疑是发育毒物，但关于儿童体内PFASs浓度及暴露途径的数据有限。我们测量了波士顿地区“活力孕期”出生队列中6至10岁儿童的血浆PFASs，并使用多变量线性回归来估计其与社会人口统计学、行为和健康相关因素以及孕期测量的母体PFASs之间的关联。“活力孕期”项目中儿童（2007 - 2010年采样）的PFASs浓度与2007 - 2008年和2009 - 2010年国家健康和营养检查调查（NHANES）中青年参与者（12 - 19岁）的浓度相似；在“活力孕期”项目和NHANES中，大多数PFASs的平均浓度从2007年到2010年都有所下降。在相互调整的模型中，PFASs浓度较高的预测因素包括儿童年龄较大、肥胖程度较低、儿童卧室有地毯、母亲教育程度较高以及邻里收入较高。与白人母亲的孩子相比，黑人母亲的孩子体内全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟己烷磺酸（PFHxS）和2 -（N - 甲基 - 全氟辛烷磺酰胺基）乙酸（Me - PFOSA - AcOH）的浓度低26 - 36%，并且母体孕期PFASs每增加一个四分位数间距，其浓度就会增加12 - 21%。在调整后的多变量模型中，母乳喂养持续时间并不能预测儿童期PFASs浓度。总体而言，所研究的预测因素仅在一定程度上解释了观察到的PFASs浓度变异性。
