Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease, Tianjin, China.
Sci Rep. 2017 Mar 21;7(1):286. doi: 10.1038/s41598-017-00383-6.
Intracerebral hemorrhage (ICH) is common in China. However, the sex differences in clinical features, risk factors, and outcomes of ICH remain controversial. Between 2005 and 2014, we recruited patients with primary ICH in Tianjin, China, and evaluated sex differences in clinical features, risk factors, and outcomes at 3, 12, and 36 months after ICH. The 1,325 patients included 897 men (67.7%) and 428 women (32.3%). The mean age at ICH onset was younger among men (59.14 years) than among women (63.12 years, P < 0.001). Men were more likely to have a hematoma in the basal ganglia, while women were more likely to have one in the thalamus. Women had higher frequencies of urinary tract infections, diabetes mellitus, cardiovascular diseases, and obesity. Men had a greater risk of death at 3 months after ICH. However, no sex differences were observed for mortality at 12 and 36 months after ICH or for recurrence and dependency at 3, 12, and 36 months after ICH. These findings suggested that it crucial to strengthen management of AF and complications in patients with ICH, especially management of blood pressure in men for reducing the mortality rates and the burden of ICH in China.
脑出血（ICH）在中国很常见。然而，ICH 的临床特征、危险因素和结局的性别差异仍存在争议。在 2005 年至 2014 年期间，我们在中国天津招募了原发性 ICH 患者，并评估了 ICH 后 3、12 和 36 个月时的临床特征、危险因素和结局的性别差异。1325 名患者中包括 897 名男性（67.7%）和 428 名女性（32.3%）。男性脑出血发病年龄较年轻（59.14 岁），女性脑出血发病年龄较年长（63.12 岁，P<0.001）。男性更有可能在基底节出现血肿，而女性更有可能在丘脑出现血肿。女性尿路感染、糖尿病、心血管疾病和肥胖的频率更高。男性脑出血后 3 个月的死亡率更高。然而，在 ICH 后 12 个月和 36 个月时，死亡率或复发和依赖率在性别之间没有差异。这些发现表明，加强对 ICH 患者房颤和并发症的管理至关重要，尤其是对男性血压的管理，以降低死亡率和 ICH 的负担。
