味精（MSG）处理小鼠的摄食行为调节

Regulation of feeding behaviour in monosodium glutamate (MSG) treated mice.

作者信息

Ma V, Ma A, Cameron D P

机构信息

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

出版信息

Life Sci. 1988;42(15):1419-24. doi: 10.1016/0024-3205(88)90051-3.

DOI:10.1016/0024-3205(88)90051-3

PMID:2832677

Abstract

Regulation of food intake was studied in mice treated neonatally with MSG. A diurnal pattern of food intake with a significantly greater nocturnal intake was observed. In response to restricted food availability (4 hours/day). MSG mice increased intake progressively although less efficiently than control mice. The opioid kappa receptor agonist ketocyclazocine enhanced food intake. It is concluded that in MSG treated mice opioid kappa receptor mechanisms involved with regulation of food intake are basically intact.

摘要

对新生期用味精（MSG）处理的小鼠的食物摄入调节进行了研究。观察到食物摄入的昼夜模式，夜间摄入量显著更高。在食物供应受限（每天4小时）的情况下，味精处理的小鼠摄入量逐渐增加，尽管效率低于对照小鼠。阿片κ受体激动剂酮环佐辛可增加食物摄入量。得出的结论是，在味精处理的小鼠中，参与食物摄入调节的阿片κ受体机制基本完好。