Yayla Çağrı, Özcan Fırat, Aras Dursun, Turak Osman, Özeke Özcan, Çay Serkan, Topaloğlu Serkan
Department of Cardiology, Türkiye Yüksek İhtisas Education & Research Hospital, Ankara, Turkey.
Biomark Med. 2017 Apr;11(4):339-346. doi: 10.2217/bmm-2016-0263. Epub 2017 Mar 14.
Tp-e/QT ratio is a novel marker of ventricular repolarization. The aim of the study is to evaluate the Tp-e interval and Tp-e/QT ratio before and after radiofrequency ablation (RFA) for patients with frequent premature ventricular complexes (PVCs).
PATIENTS & METHODS: The study included 151 consecutive patients who underwent RFA for treatment of symptomatic frequent PVCs.
Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio (all p < 0.001) were significantly different before and after RFA. After the procedure, mean left ventricular ejection fraction of the population were significantly increased than before RFA (p < 0.001). There was a significant correlation between preprocedural Tp-e/QTc ratio and PVC burden in patients (p = 0.023).
Our study shows that PVCs may have a negative effect on ventricular repolarization.
Tp-e/QT比值是心室复极的一种新型标志物。本研究的目的是评估频发室性早搏（PVC）患者在射频消融（RFA）前后的Tp-e间期和Tp-e/QT比值。
本研究纳入了151例因症状性频发PVC接受RFA治疗的连续患者。
RFA前后Tp-e间期、Tp-e/QT比值和Tp-e/QTc比值（均p<0.001）有显著差异。术后，总体人群的平均左心室射血分数较RFA前显著增加（p<0.001）。患者术前Tp-e/QTc比值与PVC负荷之间存在显著相关性（p = 0.023）。
我们的研究表明，PVC可能对心室复极有负面影响。
