Song Weixiang, Luo Yindeng, Zhao Yajing, Liu Xinjie, Zhao Jiannong, Luo Jie, Zhang Qunxia, Ran Haitao, Wang Zhigang, Guo Dajing
Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University, No. 74, Linjiang Rd, Yuzhong District, 400010 Chongqing, China.
Department of Ultrasound, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Rd, Yuzhong District, 400016 Chongqing, China.
Nanomedicine (Lond). 2017 May;12(9):991-1009. doi: 10.2217/nnm-2017-0027. Epub 2017 Mar 13.
The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging.
MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging.
PTX-USPIO-HER-NBs exhibited excellent entrapment efficiency of Herceptin/PTX/USPIO and showed greater cytotoxic effects than other delivery platforms. Low-frequency ultrasound triggered accelerated PTX release. Moreover, the magnetic nanobubbles were able to enhance ultrasound, magnetic resonance and photoacoustics trimodal imaging.
These results suggest that PTX-USPIO-HER-NBs have potential as a multimodal contrast agent and as a system for ultrasound-triggered drug release in breast cancer.
本研究的目的是通过设计具有靶向药物递送和多模态成像潜力的磁性纳米气泡来改善乳腺癌的靶向治疗。
通过将改良的双乳液蒸发工艺与碳二亚胺技术相结合，制备了用赫赛汀修饰且包载超小超顺磁性氧化铁（USPIO）/紫杉醇（PTX）的纳米气泡（PTX-USPIO-HER-NBs）。对PTX-USPIO-HER-NBs进行表征、特异性细胞靶向能力和多模态成像研究。
PTX-USPIO-HER-NBs对赫赛汀/PTX/USPIO表现出优异的包封效率，并且比其他递送平台具有更强的细胞毒性作用。低频超声触发了PTX的加速释放。此外，磁性纳米气泡能够增强超声、磁共振和光声三模态成像。
这些结果表明，PTX-USPIO-HER-NBs有潜力作为一种多模态造影剂以及作为乳腺癌中超声触发药物释放的系统。
