Jeong Jipseol, Woo Chanjin, Ip Hon S, An Injung, Kim Youngsik, Lee Kwanghee, Jo Seong-Deok, Son Kidong, Lee Saemi, Oem Jae-Ku, Wang Seung-Jun, Kim Yongkwan, Shin Jeonghwa, Sleeman Jonathan, Jheong Weonhwa
Environmental Health Research Department, National Institute of Environmental Research, Hwangyeong-ro 42, Seo-gu, Incheon, Republic of Korea.
U.S. Geological Survey, National Wildlife Health Center, Madison, WI, USA.
Virol J. 2017 Mar 21;14(1):60. doi: 10.1186/s12985-017-0731-7.
On November 20, 2016 two novel strains of H5N6 highly pathogenic avian influenza virus (HPAIVs) were isolated from three whooper swans (Cygnus cygnus) at Gangjin Bay in South Jeolla province, South Korea. Identification of HPAIVs in wild birds is significant as there is a potential risk of transmission of these viruses to poultry and humans.
Phylogenetic analysis revealed that Gangjin H5N6 viruses classified into Asian H5 clade 2.3.4.4 lineage and were distinguishable from H5N8 and H5N1 HPAIVs previously isolated in Korea. With the exception of the polymerase acidic (PA) gene, the viruses were most closely related to A/duck/Guangdong/01.01SZSGXJK005-Y/2016 (H5N6) (98.90 ~ 99.74%). The PA genes of the two novel Gangjin H5N6 viruses were most closely related to AIV isolates previously characterized from Korea, A/hooded crane/Korea/1176/2016 (H1N1) (99.16%) and A/environment/Korea/W133/2006 (H7N7) (98.65%). The lack of more recent viruses to A/environment/Korea/W133/2006 (H7N7) indicates the need for analysis of recent wild bird AIVs isolated in Korea because they might provide further clues as to the origin of these novel reassortant H5N6 viruses.
Although research on the origins and epidemiology of these infections is ongoing, the most likely route of infection for the whooper swans was through direct or indirect contact with reassortant viruses shed by migratory wild birds in Korea. As H5N6 HPAIVs can potentially be transmitted to poultry and humans, continuous monitoring of AIVs among wild birds will help to mitigate this risk.
2016年11月20日，在韩国全罗南道莞岛湾的三只大天鹅（Cygnus cygnus）中分离出两株新型H5N6高致病性禽流感病毒（HPAIVs）。野生鸟类中HPAIVs的鉴定具有重要意义，因为这些病毒有可能传播到家禽和人类身上。
系统发育分析表明，莞岛H5N6病毒属于亚洲H5进化枝2.3.4.4谱系，与韩国之前分离出的H5N8和H5N1 HPAIVs不同。除聚合酶酸性（PA）基因外，这些病毒与A/鸭/广东/01.01SZSGXJK005-Y/2016（H5N6）最为密切相关（98.90 ~ 99.74%）。两株新型莞岛H5N6病毒的PA基因与之前从韩国鉴定出的禽流感病毒分离株A/白头鹤/韩国/1176/2016（H1N1）（99.16%）和A/环境/韩国/W133/2006（H7N7）（98.65%）最为密切相关。与A/环境/韩国/W133/2006（H7N7）缺乏更近的病毒表明，有必要对韩国最近分离出的野生鸟类禽流感病毒进行分析，因为它们可能为这些新型重配H5N6病毒的起源提供进一步线索。
尽管对这些感染的起源和流行病学研究仍在进行中，但大天鹅最可能的感染途径是直接或间接接触韩国迁徙野生鸟类排出的重配病毒。由于H5N6 HPAIVs有可能传播到家禽和人类身上，持续监测野生鸟类中的禽流感病毒将有助于降低这种风险。
