Chen Wuhe, Xu Jinling, Zhou Jinjing, Gu Zhouqun, Huang Shenghai, Li Heming, Qin Zhuoer, Yu Xinping
School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
PLoS One. 2017 Mar 22;12(3):e0174537. doi: 10.1371/journal.pone.0174537. eCollection 2017.
To use highly precise spectral-domain optical coherence tomography (SD-OCT) to determine whether there were structural abnormalities in the layers of different regions of the fovea in children with anisometropic amblyopia.
Eighteen children (mean age 7.8 years old; range 5-11 years) with unilateral anisometropic amblyopia and 18 age-matched control subjects participated. Foveal thickness was measured with an enhanced depth imaging system, SD-OCT and segmented into layers using custom developed software. The thickness of each layer of the fovea was compared among amblyopic eyes, fellow eyes and control eyes with optical magnification correction for axial length and statistical correction for age and sex.
The total thickness and each intra-ocular layer of the central fovea were the same for each group. However, the amblyopic eyes were significantly thicker than the normal control eyes in 2 of 4 quadrants of the peripheral retina. Exploring intra-retinal layers in these two quadrants, the nasal nerve fiber layer (NFL) and inferior inner nuclear layer (INL)were significantly thicker in amblyopic eyes than in control eyes (p = 0.01 and 0.012, respectively, by ANCOVA).
The SD-OCT data revealed marginal differences in some foveal layers at peripheral locations and indicated that structural differences might exist between individuals with amblyopia and visually normal control subjects. However, the differences were scattered and represented no identifiable pattern. More studies with large samples and precise locations of the retinal layers must be performed to extend the present results.
使用高精度光谱域光学相干断层扫描（SD-OCT）来确定屈光参差性弱视儿童黄斑不同区域各层是否存在结构异常。
18名单侧屈光参差性弱视儿童（平均年龄7.8岁；范围5 - 11岁）和18名年龄匹配的对照受试者参与研究。使用增强深度成像系统、SD-OCT测量黄斑厚度，并使用定制开发的软件将其分层。对弱视眼、健眼和对照眼的黄斑各层厚度进行比较，并针对眼轴长度进行光学放大校正，针对年龄和性别进行统计校正。
每组中央黄斑的总厚度和各眼内层次均相同。然而，弱视眼在外周视网膜4个象限中的2个象限明显比正常对照眼厚。在这两个象限中探索视网膜内各层，弱视眼的鼻侧神经纤维层（NFL）和下方内核层（INL）明显比对照眼厚（经协方差分析，p值分别为0.01和0.012）。
SD-OCT数据显示外周位置的一些黄斑层存在细微差异，表明弱视个体与视力正常的对照受试者之间可能存在结构差异。然而，这些差异是分散的，没有可识别的模式。必须进行更多大样本且视网膜层定位精确的研究以扩展目前的结果。
