Khan Niina K, Järvelä Kati M, Loisa Eetu L, Sutinen Jaakko A, Laurikka Jari O, Khan Jahangir A
Department of Vascular Surgery, Tampere University Hospital, Tampere, Finland.
Department of Cardio-Thoracic Surgery, Heart Hospital, Tampere University Hospital, Tampere, Finland.
Interact Cardiovasc Thorac Surg. 2017 Jun 1;24(6):835-840. doi: 10.1093/icvts/ivx011.
Occurrence and risk factors of late postoperative pericardial effusions requiring invasive treatment, i.e. pretamponade and tamponade, following cardiac surgery are incompletely described in current literature. The purpose of this study was to define the incidence and presentation of late pretamponade and tamponade as well as to outline significant predisposing factors.
A cohort of 1356 consecutive cardiac surgery patients treated in a tertiary academic centre between January 2013 and December 2014 was followed up for 6 months after surgery. Pericardial effusion was considered late when presenting after the 7th postoperative day. The incidence, timing and risk factors, as well as symptoms and clinical findings associated with late pretamponade and tamponade in patients surviving at least 7 days was analysed.
Of 1308 patients included in the analysis, 81 (6.2%) underwent invasive treatment for late postoperative pericardial effusion, 27 (2.1%) for pretamponade and 54 (4.1%) for tamponade, respectively, with a median delay of 11 (range 8-87) days after the primary operation. Haemodynamic instability was present in 34.6%, signs of cardiac chamber compression in 54.3% and subjective symptoms, mostly dyspnoea, in 56.8% of patients, respectively. Treated patients were younger, had lower EuroSCORE-II rating, less coronary disease, better cardiac function, higher preoperative haemoglobin values and had mostly undergone elective surgery involving cardiac valves. In multivariable analysis, independent risk factors were single valve surgery and high preoperative haemoglobin level, whereas age 60-69 years was associated with lower risk.
Younger, generally healthier patients undergoing valve surgery are at greatest risk for developing late tamponade or pretamponade.
目前文献对心脏手术后需要进行侵入性治疗(即心包填塞前期和心包填塞)的术后晚期心包积液的发生情况和危险因素描述并不完整。本研究的目的是确定晚期心包填塞前期和心包填塞的发生率及表现,并概述重要的易感因素。
对2013年1月至2014年12月在一家三级学术中心接受连续心脏手术治疗的1356例患者进行术后6个月的随访。心包积液在术后第7天之后出现则被视为晚期。分析了至少存活7天的患者中晚期心包填塞前期和心包填塞的发生率、发生时间和危险因素,以及与之相关的症状和临床发现。
在纳入分析的1308例患者中,分别有81例(6.2%)因术后晚期心包积液接受侵入性治疗,其中27例(2.1%)为心包填塞前期,54例(4.1%)为心包填塞,初次手术后的中位延迟时间为11天(范围8 - 87天)。分别有34.6%的患者存在血流动力学不稳定,54.3%的患者有心脏腔室受压迹象,56.8%的患者有主观症状,主要为呼吸困难。接受治疗的患者更年轻,欧洲心脏手术风险评估系统(EuroSCORE-II)评分更低,冠心病更少,心功能更好,术前血红蛋白值更高,且大多接受了涉及心脏瓣膜的择期手术。在多变量分析中,独立危险因素为单瓣膜手术和术前血红蛋白水平高,而60 - 69岁年龄组的风险较低。
接受瓣膜手术的年轻且一般健康状况较好的患者发生晚期心包填塞或心包填塞前期的风险最高。