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A5202研究中药物依从性对病毒学失败的影响：一项随机、部分盲法的3B期研究

Impact of Medication Adherence on Virologic Failure in A5202: A Randomized, Partially Blinded, Phase 3B Study.

作者信息

Parker Robert A, Rabideau Dustin J, Sax Paul E, Tierney Camlin, Daar Eric S, Collier Ann C, Losina Elena, Freedberg Kenneth A

机构信息

Biostatistics Center, and.

Medical Practice Evaluation Center, Massachusetts General Hospital.

出版信息

Clin Infect Dis. 2017 Jun 1;64(11):1612-1614. doi: 10.1093/cid/cix176.

DOI:10.1093/cid/cix176
PMID:28329243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5434358/
Abstract

In AIDS Clinical Trials Group A5202, participants who reported missing their medication within the past month or not providing adherence reports at both 8 and 24 weeks had 5 times the hazard of virological failure compared to more adherent participants. Adherence interventions should focus on such patients.

摘要

在艾滋病临床试验组A5202中，报告在过去一个月内漏服药物或在第8周和第24周均未提供依从性报告的参与者发生病毒学失败的风险是依从性较好参与者的5倍。依从性干预措施应针对此类患者。

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Lancet HIV. 2014 Dec;1(3):e104-11. doi: 10.1016/S2352-3018(14)00003-4. Epub 2014 Nov 24.
2
Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final results.阿巴卡韦/拉米夫定与替诺福韦酯/恩曲他滨联合用于 HIV 初治的方案：最终结果。
J Infect Dis. 2011 Oct 15;204(8):1191-201. doi: 10.1093/infdis/jir505.
3
Atazanavir plus ritonavir or efavirenz as part of a 3-drug regimen for initial treatment of HIV-1.
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Open Forum Infect Dis. 2022 Nov 19;9(12):ofac628. doi: 10.1093/ofid/ofac628. eCollection 2022 Dec.
4
Accuracy of measures for antiretroviral adherence in people living with HIV.抗逆转录病毒药物依从性测量在 HIV 感染者中的准确性。
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AIDS Behav. 2006 May;10(3):227-45. doi: 10.1007/s10461-006-9078-6.