Razi Shajjia, Cogger Victoria C, Kennerson Marina, Benson Vicky L, McMahon Aisling C, Blyth Fiona M, Handelsman David J, Seibel Markus J, Hirani Vasant, Naganathan Vasikaran, Waite Louise, de Cabo Rafael, Cumming Robert G, Le Couteur David G
Centre for Education and Research on Ageing and the Ageing and Alzheimers Institute, University of Sydney and Concord Hospital, New South Wales, Australia.
ANZAC Research Institute and.
J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):870-876. doi: 10.1093/gerona/glx018.
The nutrient sensing protein, SIRT1 influences aging and nutritional interventions such as caloric restriction in animals, however, the role of SIRT1 in human aging remains unclear. Here, the role of SIRT1 single-nucleotide polymorphisms (SNPs) and serum-induced SIRT1 protein expression (a novel assay that detects circulating factors that influence SIRT1 expression in vitro) were studied in the Concord Health and Ageing in Men Project (CHAMP), a prospective cohort of community dwelling men aged 70 years and older. Serum-induced SIRT1 expression was not associated with age or mortality, however participants within the lowest quintile were less likely to be frail (odds ratio (OR) 0.34, 95% confidence interval (CI) 0.17-0.69, N = 1,309). Serum-induced SIRT1 expression was associated with some markers of body composition and nutrition (height, weight, body fat and lean % mass, albumin, and cholesterol) but not disease. SIRT1 SNPs rs2273773, rs3740051, and rs3758391 showed no association with age, frailty, or mortality but were associated with weight, height, body fat and lean, and albumin levels. There were some weak associations between SIRT1 SNPs and arthritis, heart attack, deafness, and cognitive impairment. There was no association between SIRT1 SNPs and the serum-induced SIRT1 assay. SIRT1 SNPs and serum-induced SIRT1 expression in older men may be more closely associated with nutrition and body composition than aging and age-related conditions.
营养感应蛋白SIRT1会影响衰老以及动物中的热量限制等营养干预措施，然而，SIRT1在人类衰老中的作用仍不清楚。在此，在一项针对70岁及以上社区居住男性的前瞻性队列研究——“男性健康与衰老协和研究项目（CHAMP）”中，研究了SIRT1单核苷酸多态性（SNP）以及血清诱导的SIRT1蛋白表达（一种检测体外影响SIRT1表达的循环因子的新方法）。血清诱导的SIRT1表达与年龄或死亡率无关，然而，处于最低五分位数的参与者虚弱的可能性较小（优势比（OR）为0.34，95%置信区间（CI）为0.17 - 0.69，N = 1309）。血清诱导的SIRT1表达与身体成分和营养的一些指标（身高、体重、体脂和瘦体重百分比、白蛋白和胆固醇）相关，但与疾病无关。SIRT1 SNPs rs2273773、rs3740051和rs3758391与年龄、虚弱或死亡率无关，但与体重、身高、体脂和瘦体重以及白蛋白水平相关。SIRT1 SNPs与关节炎、心脏病发作、耳聋和认知障碍之间存在一些微弱的关联。SIRT1 SNPs与血清诱导的SIRT1检测之间没有关联。老年男性中的SIRT1 SNPs和血清诱导的SIRT1表达可能与营养和身体成分的关系比与衰老及与年龄相关的状况更为密切。
