Centre for Education and Research on Ageing, Concord Repatriation General Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia.
J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):3-8. doi: 10.1093/gerona/glq158. Epub 2010 Sep 5.
Circulating factors that have an effect on SIRT1 expression are influenced by caloric restriction. To determine the association between frailty and such circulating factors, we measured serum-induced SIRT1 expression from a nested cohort of frail (n = 77) and robust (n = 82) participants from Concord Health and Ageing in Men Project, a population-based study of community-dwelling men older than 70 years. Serum-induced SIRT1 expression was not different between frail and robust men (103.1 ± 17.0 versus 100.4 ± 19.3 μg/L). However, subsequent analyses showed that men with the lowest values (first quartile) were less likely to be frail (odds ratio = 0.5, 95% confidence interval = 0.2-1.0, p = .04) and had higher total body lean mass (p = .001) than the other participants. Serum-induced SIRT1 expression did not correlate with age, diseases, medications, albumin, fasting glucose, or lipids. Overall, there was no association between frailty and serum-induced SIRT1 expression; however, post hoc analysis suggested that there might be a paradoxical association between low serum-induced SIRT1 expression and robustness.
影响 SIRT1 表达的循环因子受热量限制的影响。为了确定虚弱与这些循环因子之间的关系，我们从 Concord Health and Ageing in Men Project 的一个嵌套队列中测量了虚弱（n=77）和强壮（n=82）参与者的血清诱导的 SIRT1 表达，该队列是一项针对 70 岁以上社区居住男性的基于人群的研究。血清诱导的 SIRT1 表达在虚弱和强壮男性之间没有差异（103.1±17.0 与 100.4±19.3μg/L）。然而，进一步的分析表明，血清中 SIRT1 表达最低（第一四分位数）的男性不太可能虚弱（比值比=0.5，95%置信区间=0.2-1.0，p=0.04），并且具有更高的全身瘦体重（p=0.001）比其他参与者。血清诱导的 SIRT1 表达与年龄、疾病、药物、白蛋白、空腹血糖或脂质无关。总的来说，虚弱与血清诱导的 SIRT1 表达之间没有关联；然而，事后分析表明，低血清诱导的 SIRT1 表达与健壮之间可能存在一种矛盾的关联。
