重新思考环二核苷酸的感应。
RECONsidering Sensing of Cyclic Dinucleotides.
机构信息
Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
出版信息
Immunity. 2017 Mar 21;46(3):337-339. doi: 10.1016/j.immuni.2017.03.005.
Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state.
STING 通路检测环二核苷酸（cdNs）可有效地触发抗病毒反应。McFarland 等人现在表明，小鼠氧化还原酶 RECON 可作为某些细菌 cdNs 的传感器，以独立于 STING 的方式调节先天信号，促进抗菌状态，从而调节先天信号。
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