社会联系、感知孤独与痴呆：社会环境是否调节遗传风险与认知健康之间的关系？
Social Connectedness, Perceived Isolation, and Dementia: Does the Social Environment Moderate the Relationship Between Genetic Risk and Cognitive Well-Being?
机构信息
Center on Aging, College of Human Ecology, Kansas State University, Manhattan.
Department of Gerontology, McCormack Graduate School of Policy and Global Studies, University of Massachusetts, Boston.
出版信息
Gerontologist. 2017 Nov 10;57(6):1031-1040. doi: 10.1093/geront/gnw154.
PURPOSE OF THE STUDY
This study examined whether the social environment moderates the relationship between the APOE e4 allele and cognitive functioning.
DESIGN AND METHODS
The Aging, Demographics, and Memory Study (ADAMS) data and multinomial logistic regression models were used to investigate these relationships for a nationally representative sample of U.S. adults aged 70 and older (n = 779).
RESULTS
Living alone (relative risk ratio [RRR] = 5.814; p = .000) and self-reported loneliness (RRR = 1.928, p = .049) were associated with a greater risk of cognitive difficulty. Living arrangements, perceived social support, and loneliness were found to moderate the relationship between the APOE e4 allele and cognitive function.
IMPLICATIONS
The results support the need to consider the social context when examining cognitive well-being in later life. These findings also indicate a need for the development of policies and services that promote a rich social environment.
研究目的
本研究旨在探讨社会环境是否调节载脂蛋白 E4 等位基因与认知功能之间的关系。
设计与方法
本研究使用老龄化、人口统计学和记忆研究（ADAMS）的数据和多项逻辑回归模型，针对美国 70 岁及以上的具有全国代表性的成年人样本（n=779）进行了这些关系的调查。
结果
独居（相对风险比 [RRR] = 5.814；p =.000）和自述孤独（RRR = 1.928，p =.049）与认知困难的风险增加相关。研究发现，生活安排、感知到的社会支持和孤独感调节了载脂蛋白 E4 等位基因与认知功能之间的关系。
意义
研究结果支持在研究晚年认知健康时需要考虑社会背景。这些发现还表明，需要制定促进丰富社会环境的政策和服务。
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