Puntoni R, Goldsmith D F, Valerio F, Vercelli M, Bonassi S, Di Giorgio F, Ceppi M, Stagnaro E, Filiberti R, Santi L
Dipartimento di Epidemiologia e Biostatistica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italia.
Tumori. 1988 Feb 29;74(1):27-33. doi: 10.1177/030089168807400105.
A mortality study was carried out on a cohort of workers who were exposed to silica dust in a refractory brick plant. The cohort was divided into two groups: workers with and without silicosis, and their mortality was contrasted with the death rate of Genova from 1960 to 1979. Results show an increased risk for laryngeal tumors (3 obs., 0.44 exp., SMR = 682), nonmalignant respiratory disease (16 obs., 3.2 exp., SMR = 500), and cardiovascular diseases (19 obs., 11 exp., SMR = 173) among silicotics. The mortality rate for lung cancer showed an increase for the cohort of workers as a whole (11 obs., 6 exp., SMR = 183). The almost double overall mortality observed in silicotic subjects raises some doubts about the validity of other proportional mortality studies that showed no excesses for workers in these industries.
对耐火砖厂中接触矽尘的一组工人进行了死亡率研究。该队列分为两组：患有矽肺病和未患矽肺病的工人，并将他们的死亡率与1960年至1979年热那亚的死亡率进行了对比。结果显示，矽肺病患者患喉肿瘤（观察到3例，预期0.44例，标准化死亡比=682）、非恶性呼吸道疾病（观察到16例，预期3.2例，标准化死亡比=500）和心血管疾病（观察到19例，预期11例，标准化死亡比=173）的风险增加。整个工人群体的肺癌死亡率有所上升（观察到11例，预期6例，标准化死亡比=183）。在矽肺病患者中观察到的总体死亡率几乎翻倍，这对其他比例死亡率研究的有效性提出了一些质疑，这些研究表明这些行业的工人没有超额死亡率。
