Haidari Fatemeh, Shahi Majid M, Zarei Mehdi, Rafiei Hossein, Omidian Kosar
Nutrition Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Saudi Med J. 2012 Feb;33(2):128-33.
To examine the effect of green tea extract on body weight, serum levels of glucose, and lipids in streptozotocin-induced diabetic rats.
This experimental study was carried out in the Diabetes Research Center, Ahvaz University of Medical Sciences, Ahvaz, Iran from January 2011 to March 2011. Forty-eight male wistar rats (200-250 g) were divided randomly into 6 groups. Diabetes was induced by a single intraperitoneal injection of stereptozotocin (55 mg/kg). The experimental groups received alcohol extract of green tea leaves (100 mg/kg and 200 mg/kg) for 4 weeks and the body weight of animals were measured every day. Finally, blood samples were collected and analyzed for glucose and lipid profile levels.
Administration of green tea extract caused a significant decrease in serum glucose and total cholesterol levels and significantly improved the body weight loss in diabetic rats treated with 200 mg/kg green tea in comparison to diabetic control group. No significant changes were observed in triglyceride (p=0.04), low-density-lipoprotein cholesterol (p=0.000), and high-density-lipoprotein cholesterol levels (p=0.01) following intervention.
It appears that green tea extract had both antihyperglycemic and hypocholesterolmic effects in diabetic rats, although further work is needed to determine their mechanism.
研究绿茶提取物对链脲佐菌素诱导的糖尿病大鼠体重、血糖水平及血脂的影响。
本实验研究于2011年1月至2011年3月在伊朗阿瓦士医科大学糖尿病研究中心进行。48只雄性Wistar大鼠（200 - 250克）随机分为6组。通过单次腹腔注射链脲佐菌素（55毫克/千克）诱导糖尿病。实验组接受绿茶叶乙醇提取物（100毫克/千克和200毫克/千克），持续4周，每天测量动物体重。最后，采集血样并分析血糖和血脂水平。
与糖尿病对照组相比，给予绿茶提取物后，血清葡萄糖和总胆固醇水平显著降低，且给予200毫克/千克绿茶治疗的糖尿病大鼠体重减轻情况得到显著改善。干预后，甘油三酯（p = 0.04）、低密度脂蛋白胆固醇（p = 0.000）和高密度脂蛋白胆固醇水平（p = 0.01）未见显著变化。
绿茶提取物在糖尿病大鼠中似乎具有降血糖和降胆固醇作用，尽管需要进一步研究以确定其作用机制。
