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本文引用的文献

1
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.发育期 CA1 海马 α4βδ GABAA 受体表达减少癫痫样放电。
Sci Rep. 2016 Aug 26;6:31928. doi: 10.1038/srep31928.
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Catamenial Epilepsy: Discovery of an Extrasynaptic Molecular Mechanism for Targeted Therapy.经期癫痫：靶向治疗的突触外分子机制的发现
Front Cell Neurosci. 2016 Apr 22;10:101. doi: 10.3389/fncel.2016.00101. eCollection 2016.
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During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons.在出生后的发育过程中，内源性神经甾体影响小鼠皮层神经元的γ-氨基丁酸能神经传递。
Neuropharmacology. 2016 Apr;103:163-73. doi: 10.1016/j.neuropharm.2015.11.019. Epub 2015 Dec 2.
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Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.动情周期对 extrasynaptic δ 包含 GABA(A) 受体介导的紧张性抑制和边缘性癫痫发生的调节。
J Pharmacol Exp Ther. 2013 Jul;346(1):146-60. doi: 10.1124/jpet.113.203653. Epub 2013 May 10.
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LGI2 truncation causes a remitting focal epilepsy in dogs.LGI2 截短导致犬发作性局灶性癫痫。
PLoS Genet. 2011 Jul;7(7):e1002194. doi: 10.1371/journal.pgen.1002194. Epub 2011 Jul 28.
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Neurosteroids: endogenous role in the human brain and therapeutic potentials.神经甾体：在人类大脑中的内源性作用和治疗潜力。
Prog Brain Res. 2010;186:113-37. doi: 10.1016/B978-0-444-53630-3.00008-7.
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The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors.睾酮衍生的神经甾体雄烷二醇是 GABAA 受体的正变构调节剂。
J Pharmacol Exp Ther. 2010 Sep 1;334(3):1031-41. doi: 10.1124/jpet.110.169854. Epub 2010 Jun 15.
8
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.alpha4betadelta GABAA 受体在塑造青春期小鼠学习缺陷方面的关键作用。
Science. 2010 Mar 19;327(5972):1515-8. doi: 10.1126/science.1184245.
9
Neurosteroid regulation of GABA(A) receptors: Focus on the alpha4 and delta subunits.神经甾体对γ-氨基丁酸A型（GABA(A)）受体的调节：聚焦于α4和δ亚基
Pharmacol Ther. 2007 Oct;116(1):58-76. doi: 10.1016/j.pharmthera.2007.03.008. Epub 2007 Apr 21.
10
Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty.青春期时，α4β2δγ-氨基丁酸A型（GABAA）受体处神经甾体效应的逆转引发焦虑。
Nat Neurosci. 2007 Apr;10(4):469-77. doi: 10.1038/nn1868. Epub 2007 Mar 11.

Calming Down During Coming of Age.

作者信息

Maguire Jamie

出版信息

Epilepsy Curr. 2017 Jan-Feb;17(1):57-59. doi: 10.5698/1535-7511-17.1.57.

DOI:10.5698/1535-7511-17.1.57
PMID:28331476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5340562/
Abstract
摘要