Özdemir Altan, Mayir Burhan, Demirbakan Kenan, Oygür Nezihi
Department of General Surgery, Bucak State Hospital, Burdur, Turkey.
Department of General Surgery, Antalya Education and Research Hospital, Antalya, Turkey.
J Breast Health. 2014 Apr 1;10(2):88-91. doi: 10.5152/tjbh.2014.1914. eCollection 2014 Apr.
Sentinel lymph node biopsy is the recommended approach in the evaluation of axilla during breast cancer surgery. In this study, results of patients who underwent methylene blue sentinel lymph node biopsy were evaluated.
The study included 32 female patients with T1 and T2 tumors. 5 ml of 1% methylene blue was injected into the peritumoral area or around the cavity. The axillary sentinel lymph node was found and removed, and then axillary dissection was performed. The sentinel lymph node and axillary dissection specimen were histopathologically examined and the results were compared.
The sentinel lymph node was found in 30 (94%) patients. Lymph node metastasis was not observed in 17 patients in both the sentinel lymph node and axilla. Two patients had metastasis in the axilla although this was not detected in sentinel lymph node. Eleven patients had metastasis both in the sentinel lymph node and in the axilla. The accuracy rate was 93%, and the false negativity rate was identified as 15%.
Sentinel lymph node biopsy by methylene blue is a method that can be applied with high accuracy. Methylene blue can be considered as an alternative to isosulphane blue in sentinel lymph node biopsy.
前哨淋巴结活检是乳腺癌手术中评估腋窝的推荐方法。在本研究中，对接受亚甲蓝前哨淋巴结活检的患者结果进行了评估。
该研究纳入了32例患有T1和T2肿瘤的女性患者。将5毫升1%的亚甲蓝注入肿瘤周围区域或腔隙周围。找到并切除腋窝前哨淋巴结，然后进行腋窝清扫。对前哨淋巴结和腋窝清扫标本进行组织病理学检查并比较结果。
30例（94%）患者找到前哨淋巴结。17例患者的前哨淋巴结和腋窝均未观察到淋巴结转移。2例患者腋窝有转移，但在前哨淋巴结中未检测到。11例患者的前哨淋巴结和腋窝均有转移。准确率为93%，假阴性率为15%。
亚甲蓝前哨淋巴结活检是一种可高精度应用的方法。在进行前哨淋巴结活检时，亚甲蓝可被视为异硫蓝的替代物。
