Hashemi Hassan, Khabazkhoob Mehdi, Yekta AbbasAli, Emamian Mohammad Hassan, Nabovati Payam, Fotouhi Akbar
a Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital , Tehran , Iran.
b Noor Ophthalmology Research Center, Noor Eye Hospital , Tehran , Iran.
Ophthalmic Epidemiol. 2017 Oct;24(5):323-331. doi: 10.1080/09286586.2017.1290808. Epub 2017 Mar 23.
To determine the distribution of macular thickness in a healthy Iranian population aged 45-69 years and its association with certain determinants.
All participants underwent optometric examinations including measurement of uncorrected and corrected visual acuity, objective refraction by retinoscopy, and subjective refraction. Subsequently, all participants underwent slit-lamp biomicroscopy followed by fundus examination through direct and indirect ophthalmoscopy, and optical coherence tomography (OCT) imaging under pupil dilation.
Mean central macular thickness was 255.4 µm (95% confidence interval, CI, 254.5-256.3 µm), average inner macular thickness was 316.5 µm (95% CI 315.9-317.1 µm), average outer macular thickness was 275.3 µm (95% CI 274.8-275.8 µm), and overall average thickness was 278.6 µm (95% CI 278.1-279.1 µm). A linear multiple regression model showed that all indexes were significantly larger in male participants (p < 0.001). Central macular thickness increased with age (coef = 0.25, p < 0.001) while overall, inner and outer macular thickness decreased with age (coef = -0.18, -0.15, -0.19, respectively, all p < 0.001). Central and inner macular thickness had a positive correlation (coef = 3.8, 2.6, respectively, both p < 0.001) and outer macular thickness had a negative correlation (coef = -1.6, p < 0.001) with axial length.
Age, sex, refractive error, axial length, and keratometry were found to be associated with macular thickness. These factors should be taken into account when interpreting macular thickness measurements with spectral-domain OCT.
确定年龄在45 - 69岁的健康伊朗人群黄斑厚度的分布情况及其与某些决定因素的关联。
所有参与者均接受验光检查，包括测量未矫正和矫正视力、视网膜检影法进行客观验光以及主观验光。随后，所有参与者接受裂隙灯生物显微镜检查，接着通过直接和间接检眼镜进行眼底检查，并在瞳孔散大状态下进行光学相干断层扫描（OCT）成像。
平均中心黄斑厚度为255.4 µm（95%置信区间，CI，254.5 - 256.3 µm），平均黄斑内层厚度为316.5 µm（95% CI 315.9 - 317.1 µm），平均黄斑外层厚度为275.3 µm（95% CI 274.8 - 275.8 µm），总体平均厚度为278.6 µm（95% CI 278.1 - 279.1 µm）。线性多元回归模型显示，男性参与者的所有指标均显著更大（p < 0.001）。中心黄斑厚度随年龄增加（系数 = 0.25，p < 0.001），而总体、黄斑内层和外层厚度随年龄下降（系数分别为 -0.18、-0.15、-0.19，均p < 0.001）。中心和黄斑内层厚度与眼轴长度呈正相关（系数分别为3.8、2.6，均p < 0.001），黄斑外层厚度与眼轴长度呈负相关（系数 = -1.6，p < 0.001）。
发现年龄、性别（应为“性别”，原文“sexuality”有误）、屈光不正、眼轴长度和角膜曲率与黄斑厚度相关。在使用光谱域OCT解释黄斑厚度测量结果时应考虑这些因素。
