Schuster Alexander Karl-Georg, Fischer Joachim Ernst, Vossmerbaeumer Urs
Mannheim Institute of Public Health (MIPH), Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Graefes Arch Clin Exp Ophthalmol. 2015 Jan;253(1):121-5. doi: 10.1007/s00417-014-2781-5. Epub 2014 Sep 26.
Beyond in-vivo histological analysis of retinal tissue, optical coherence tomography (OCT) allows quantitative image analysis. This study evaluates associations of macular retinal thickness measured with spectral-domain OCT (SD-OCT) and ocular and systemic cardiovascular parameters in adult subjects.
An epidemiological cross-sectional study was performed in the staff of a European high-tech company. Examination of known cardiovascular risk factors including biochemical blood analysis was performed, and ocular parameters such as refraction, tonometry, SD-OCT imaging of the macula and cornea, and fundus photography were evaluated. Retinal thickness measurements were evaluated according to the ETDRS grid. Associations of macular retinal thickness and systemic cardiovascular and ocular parameters were calculated by multivariate analysis using SPSS software.
Four hundred and twenty-four probands were included. Macular thickness measurement were significantly associated with gender and refraction. Female persons had thinner retinal thickness in all zones. Macular thickness decreased with increasing myopia in all perifoveal measurements. Outer perifoveal measurements were associated with keratometry; a flatter corneal radius was linked to a thinner retina. Tonometry and systemic cardiovascular risk factors were not associated with macular retinal thickness in multivariate analysis (p > 0.05).
Macular retinal thickness is associated with refraction and gender; cardiovascular risk factors or tonometry do not influence macular retinal thickness measurements. Keratometry might influence outer zone measurements. Our findings provide a dataset for quantitative evaluation of SD-OCT, and evaluate influencing factors.
除了对视网膜组织进行体内组织学分析外，光学相干断层扫描（OCT）还可进行定量图像分析。本研究评估了在成年受试者中，用光谱域OCT（SD - OCT）测量的黄斑视网膜厚度与眼部及全身心血管参数之间的关联。
对一家欧洲高科技公司的员工进行了一项流行病学横断面研究。检查了包括血液生化分析在内的已知心血管危险因素，并评估了诸如验光、眼压测量、黄斑和角膜的SD - OCT成像以及眼底照相术等眼部参数。根据ETDRS网格评估视网膜厚度测量值。使用SPSS软件通过多变量分析计算黄斑视网膜厚度与全身心血管和眼部参数之间的关联。
纳入了424名受试者。黄斑厚度测量值与性别和验光显著相关。女性在所有区域的视网膜厚度均较薄。在所有黄斑周围测量中，黄斑厚度随着近视程度的增加而降低。黄斑周围外侧测量值与角膜曲率测量相关；角膜半径越扁平，视网膜越薄。在多变量分析中，眼压测量和全身心血管危险因素与黄斑视网膜厚度无关（p＞0.05）。
黄斑视网膜厚度与验光和性别有关；心血管危险因素或眼压测量不影响黄斑视网膜厚度测量。角膜曲率测量可能影响外侧区域测量。我们的研究结果为SD - OCT的定量评估提供了一个数据集，并评估了影响因素。
