Postgraduate School of Hygiene and Preventive Medicine, University of Ferrara, 44121 Ferrara, Italy.
Azienda USL Bologna, Registro Tumori Area Vasta Emilia Centrale, 40124 Bologna, Italy.
J Public Health (Oxf). 2017 Dec 1;39(4):730-737. doi: 10.1093/pubmed/fdx025.
Human papillomavirus (HPV) infection is the main cause of cervical cancer and plays a relevant role in the development of genital warts and of the cancer of penis and anus, head/neck, oropharynx and genitourinary system. The aim of this study is the evaluation of hospitalizations due to HPV-related pathologies in 2001-12 in Italy.
The national hospital discharge forms were provided by the Ministry of Health. The HPV-related hospitalizations were identified using specific diagnostic codes, accordingly to the ICD-9-CM coding system. The proportion of hospitalizations of potentially HPV-related pathologies, obtained from the literature, was evaluated as well as the hospitalization rates (hr) and their trend over time.
Uterine cervical cancer and CIN III accounted for 40% of hospitalizations (hr: 15.6/100 000 and 17.6/100 000, respectively). Head/neck and oropharynx pathologies accounted for 24.5% of cases (hr: 16/100 000 and 3.9/100 000, in males and females, respectively), followed by genital warts (17.3% of hospitalizations; hr: 7.5/100 000 in males and 8.52/100 000 in females), anal (8.1% of hospitalizations), genitourinary (7.7%) and penis cancers (2.2%).
The study, even if limited to the evaluation of hospitalizations, points out how HPV-related pathologies continue to be a relevant public health issue in Italy with a high impact on population.
人乳头瘤病毒（HPV）感染是宫颈癌的主要病因，与生殖器疣以及阴茎、肛门、头颈部、口咽和泌尿生殖系统癌症的发生发展密切相关。本研究旨在评估 2001-12 年意大利因 HPV 相关疾病住院的情况。
卫生部提供了全国住院表单。根据国际疾病分类第 9 版临床修正（ICD-9-CM）编码系统，采用特定的诊断代码来识别 HPV 相关住院病例。此外，还评估了文献中报道的潜在 HPV 相关疾病的住院比例，以及住院率（HR）及其随时间的变化趋势。
子宫颈癌和 CIN III 分别占住院病例的 40%（HR：15.6/10 万和 17.6/10 万）。头颈部和口咽部位的疾病占病例的 24.5%（HR：男性 16/10 万，女性 3.9/10 万），其次是生殖器疣（占住院病例的 17.3%；HR：男性 7.5/10 万，女性 8.52/10 万）、肛门癌（8.1%）、泌尿生殖系统癌（7.7%）和阴茎癌（2.2%）。
本研究虽然仅限于住院评估，但指出 HPV 相关疾病在意大利仍然是一个重要的公共卫生问题，对人群健康有重大影响。
