Baldo Vincenzo, Cocchio Silvia, Buja Alessandra, Baldovin Tatjana, Furlan Patrizia, Bertoncello Chiara, Saia Mario
Department of Molecular Medicine, Public Health Section, Istituto di Igiene, University of Padua, Via Loredan, 18, 35121 Padova, Italy.
BMC Infect Dis. 2013 Oct 5;13:462. doi: 10.1186/1471-2334-13-462.
Human papillomavirus (HPV) is one of the most common sexually-transmitted pathogens. A number of studies in the literature have estimated the burden of HPV-related diseases by collecting data at primary care level, while a comprehensive assessment of the global burden of HPV-related diseases on hospital resources is still lacking.
This was a retrospective cohort study based on hospital discharge data collected from 2000 to 2010 in the Veneto Region (north-east Italy). All hospitalizations for diseases potentially associated with HPV were identified by searching the hospital discharge records, then the proportion of these hospitalizations relating to diseases attributable to the HPV infection was calculated.
Overall, the annual hospitalization rate for HPV-related diseases was 21.3 per 100,000 individuals in the general population, 15.8 per 100,000 males, and 27.6 per 100,000 females. Hospitalizations were due mainly to genital warts, and peak among 15- to 44-year-olds in both genders. Taking both sexes together, the hospitalizations attributable to HPV dropped from 24.5/100,000 in 2000 to 17.5/100,000 in 2011, showing a significant decline during this period, with an average annual percent change (AAPC) of -1.9% (CI 95%: -2.8, -0.9;). On the other hand, the hospitalization rate for genital warts tended to increase significantly (AAPC 3.0% [CI 95%: 1.4;4.7]), whilst there was a significantly declining trend in the hospitalization rate for anal cancer (AAPC - 5.0% [CI 95%: -7.7;-2.2]), genital cancer (AAPC -6.2% [CI 95%: -7.8;-4.6]) and oropharyngeal cancer (AAPC -4.3% [CI 95%: -4.8;-3,8]).
Data derived from the hospital records indicate that HPV-related diseases are an important public health issue.
人乳头瘤病毒（HPV）是最常见的性传播病原体之一。文献中的多项研究通过在初级保健层面收集数据来估计HPV相关疾病的负担，然而，目前仍缺乏对HPV相关疾病对医院资源造成的全球负担的全面评估。
这是一项基于2000年至2010年在意大利东北部威尼托地区收集的医院出院数据的回顾性队列研究。通过检索医院出院记录，确定所有可能与HPV相关疾病的住院病例，然后计算这些住院病例中归因于HPV感染疾病的比例。
总体而言，普通人群中HPV相关疾病的年住院率为每10万人21.3例，男性为每10万人15.8例，女性为每10万人27.6例。住院主要是由于尖锐湿疣，且在15至44岁的两性中达到峰值。综合两性来看，归因于HPV的住院率从2000年的每10万人24.5例降至2011年的每10万人17.5例，在此期间呈显著下降，平均年变化百分比（AAPC）为-1.9%（95%置信区间：-2.8，-0.9）。另一方面，尖锐湿疣的住院率呈显著上升趋势（AAPC 3.0% [95%置信区间：1.4；4.7]），而肛门癌（AAPC -5.0% [95%置信区间：-7.7；-2.2]）、生殖器癌（AAPC -6.2% [95%置信区间：-7.8；-4.6]）和口咽癌（AAPC -4.3% [95%置信区间：-4.8；-3.8]）的住院率则呈显著下降趋势。
来自医院记录的数据表明，HPV相关疾病是一个重要的公共卫生问题。
