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随着时间推移在神经退行性疾病中实施补偿。

Operationalizing compensation over time in neurodegenerative disease.

机构信息

Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK.

Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa, City, IA, USA.

出版信息

Brain. 2017 Apr 1;140(4):1158-1165. doi: 10.1093/brain/awx022.

Abstract

In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long . present two mathematical models of compensation over time and their operationalisation for neuroimaging.

摘要

在临床前亨廷顿病中,尽管神经退行性变仍保持正常行为,表明存在一种补偿机制。Gregory 和 Long 提出了两种随时间补偿的数学模型及其神经影像学的实现方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/5382953/3dac307c635f/awx022f1.jpg

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