Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK.
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa, City, IA, USA.
Brain. 2017 Apr 1;140(4):1158-1165. doi: 10.1093/brain/awx022.
In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long . present two mathematical models of compensation over time and their operationalisation for neuroimaging.
在临床前亨廷顿病中,尽管神经退行性变仍保持正常行为,表明存在一种补偿机制。Gregory 和 Long 提出了两种随时间补偿的数学模型及其神经影像学的实现方法。