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黑色素相关的表面增强拉曼散射活性纳米结构的合成及其在监测细胞内黑色素生成中的应用

Melanin-Associated Synthesis of SERS-Active Nanostructures and the Application for Monitoring of Intracellular Melanogenesis.

作者信息

Dong Haixin, Liu Zhiming, Zhong Huiqing, Yang Hui, Zhou Yan, Hou Yuqing, Long Jia, Lin Jin, Guo Zhouyi

机构信息

SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou 510631, China.

Infinitus (China) Company Ltd., Guangzhou 510665, China.

出版信息

Nanomaterials (Basel). 2017 Mar 20;7(3):70. doi: 10.3390/nano7030070.

DOI:10.3390/nano7030070
PMID:28336903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5388172/
Abstract

Melanin plays an indispensable role in the human body. It serves as a biological reducer for the green synthesis of precious metal nanoparticles. Melanin-Ag nanocomposites were successfully produced which exhibited very strong surface-enhanced Raman scattering (SERS) effect because of the reducibility property of melanin. A melanin-Ag composite structure was synthesized in situ in melanin cells, and SERS technique was performed for the rapid imaging and quantitative assay of intracellular melanin. This imaging technique was also used to successfully trace the formation and secretion of intracellular melanin after stimulation with melanin-stimulating hormones. Based on the self-reducing property of melanin, the proposed SERS imaging method can provide potentially powerful analytical detection tools to study the biological functions of melanin and to prevent and cure melanin-related diseases.

摘要

黑色素在人体中起着不可或缺的作用。它作为贵金属纳米颗粒绿色合成的生物还原剂。成功制备了黑色素 - 银纳米复合材料，由于黑色素的还原性，该复合材料表现出非常强的表面增强拉曼散射（SERS）效应。在黑色素细胞中原位合成了黑色素 - 银复合结构，并利用SERS技术对细胞内黑色素进行快速成像和定量分析。该成像技术还成功用于追踪黑色素刺激激素刺激后细胞内黑色素的形成和分泌。基于黑色素的自还原特性，所提出的SERS成像方法可为研究黑色素的生物学功能以及预防和治疗黑色素相关疾病提供潜在强大的分析检测工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/8d8f6edb69e9/nanomaterials-07-00070-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/ae4de30de904/nanomaterials-07-00070-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/f3c88718a3c4/nanomaterials-07-00070-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/ef2468a816ad/nanomaterials-07-00070-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/9b0cc71cef9c/nanomaterials-07-00070-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/92538ceb81b7/nanomaterials-07-00070-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/8d8f6edb69e9/nanomaterials-07-00070-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/ae4de30de904/nanomaterials-07-00070-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/f3c88718a3c4/nanomaterials-07-00070-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/ef2468a816ad/nanomaterials-07-00070-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/9b0cc71cef9c/nanomaterials-07-00070-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/92538ceb81b7/nanomaterials-07-00070-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b4/5388172/8d8f6edb69e9/nanomaterials-07-00070-g006.jpg

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