Wu Victor J, Pang Darren, Tang Wendell W, Zhang Xin, Li Li, You Zongbing
Department of Structural & Cellular Biology, Tulane UniversityNew Orleans, LA, USA; Department of Orthopaedic Surgery, Tulane UniversityNew Orleans, LA, USA.
Laboratory of Translational Cancer Research, Ochsner Clinic Foundation New Orleans, LA, USA.
Am J Clin Exp Urol. 2017 Feb 15;5(1):1-9. eCollection 2017.
Approximately 36.5% of the U.S. adults (≥ 20 years old) are obese. Obesity has been associated with type 2 diabetes mellitus, cardiovascular disease, stroke, and several types of cancer. The present study included 1788 prostate cancer patients who were treated with radical prostatectomy at the Ochsner Health System, New Orleans, Louisiana, from January, 2001 to March, 2016. The patient's medical records were retrospectively reviewed. Body mass index (BMI), age, ethnicity (Caucasians versus African Americans), clinical stage, Gleason score, and prostate-specific antigen (PSA) levels were retrieved. The relative risk of the patients was stratified into low risk and high risk groups. Associative analyses found that BMI was associated with age, clinical stage, Gleason score, but not ethnicity, PSA levels, or the relative risk in this cohort. Age was associated with ethnicity, clinical stage, Gleason score, and PSA levels, as well as the relative risk. Ethnicity was associated with Gleason score and PSA levels as well as the relative risk, but not clinical stage. These findings suggest that obesity is associated with advanced prostate cancer with stage T3 or Gleason score ≥ 7 diseases, and age and ethnicity are important factors that are associated with the clinical features of prostate cancer patients.
约36.5%的美国成年人（≥20岁）患有肥胖症。肥胖症与2型糖尿病、心血管疾病、中风以及几种类型的癌症有关。本研究纳入了2001年1月至2016年3月期间在路易斯安那州新奥尔良市奥施纳医疗系统接受根治性前列腺切除术的1788例前列腺癌患者。对患者的病历进行了回顾性审查。获取了体重指数（BMI）、年龄、种族（白种人与非裔美国人）、临床分期、 Gleason评分和前列腺特异性抗原（PSA）水平。将患者的相对风险分为低风险和高风险组。关联分析发现，在该队列中，BMI与年龄、临床分期、Gleason评分相关，但与种族、PSA水平或相对风险无关。年龄与种族、临床分期、Gleason评分、PSA水平以及相对风险相关。种族与Gleason评分、PSA水平以及相对风险相关，但与临床分期无关。这些发现表明，肥胖与T3期或Gleason评分≥7的晚期前列腺癌相关，年龄和种族是与前列腺癌患者临床特征相关的重要因素。
