Ye Jing, Shen Caihong, Huang Yayan, Zhang Xueqin, Xiao Meitian
College of Chemical Engineering, Huaqiao University, Xiamen, China.
J Sci Food Agric. 2017 Oct;97(13):4548-4556. doi: 10.1002/jsfa.8322. Epub 2017 Apr 27.
Sea cucumber (Stichopus japonicus) is a well-known nutritious and luxurious seafood in Asia which has attracted increasing attention because of its nutrition and bioactivities in recent years. In this study, the anti-fatigue activity of sea cucumber peptides (SCP) prepared from S. japonicus was evaluated in a load-induced endurance swimming model.
The SCP prepared in this study was mainly made up of low-molecular-weight peptides (<2 kDa). The analysis result of amino acid composition revealed that SCP was rich in glycine, glutamic acid and proline. The endurance capability of rats to fatigue was significantly improved by SCP treatment. Meanwhile, the remarkable alterations of energy metabolic markers, antioxidant enzymes, antioxidant capacity and oxidative stress biomarkers were normalized. Moreover, administration of SCP could modulate alterations of inflammatory cytokines and downregulate the overexpression of TRL4 and NF-κB.
SCP has anti-fatigue activity and it exerted its anti-fatigue effect probably through normalizing energy metabolism as well as alleviating oxidative damage and inflammatory responses. © 2017 Society of Chemical Industry.
海参（刺参）是亚洲一种著名的营养丰富且高档的海鲜，近年来因其营养成分和生物活性而受到越来越多的关注。在本研究中，利用负荷诱导的耐力游泳模型评估了从刺参制备的海参肽（SCP）的抗疲劳活性。
本研究制备的SCP主要由低分子量肽（<2 kDa）组成。氨基酸组成分析结果表明，SCP富含甘氨酸、谷氨酸和脯氨酸。SCP处理显著提高了大鼠的抗疲劳能力。同时，能量代谢标志物、抗氧化酶、抗氧化能力和氧化应激生物标志物的显著变化恢复正常。此外，给予SCP可调节炎性细胞因子的变化，并下调TRL4和NF-κB的过表达。
SCP具有抗疲劳活性，其抗疲劳作用可能是通过使能量代谢正常化以及减轻氧化损伤和炎症反应来实现的。© 2017化学工业协会。
