G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, Russia.
Faculty of Biology and Biotechnology, National Research University Higher School of Economics, 13/4 Myasnitskaya Str., Moscow 117997, Russia.
Int J Mol Sci. 2024 Nov 10;25(22):12068. doi: 10.3390/ijms252212068.
Matrikines (MKs), the products of enzymatic fragmentation of various extracellular matrix (ECM) proteins, regulate cellular activity by interacting with specific receptors. MKs affect cell growth, proliferation, and migration, can induce apoptosis and autophagy, and are also effectively used in biomedicine and functional nutrition. Recently, there has been great interest in the structural features and biological activity of MKs from various sources. This review summarized and analyzed the results of modern research on MKs from sea cucumbers, primarily from trepang (MKT). Particular attention is paid to the analysis of the existing knowledge on the antioxidant, anti-inflammatory and adaptogenic activities of these MKs and the possible mechanisms of their protective action.
基质细胞衍生因子（MKs）是各种细胞外基质（ECM）蛋白酶解的产物，通过与特定受体相互作用来调节细胞活性。MKs 影响细胞的生长、增殖和迁移，能够诱导细胞凋亡和自噬，并且在生物医药和功能性营养中也得到了有效应用。最近，人们对来自各种来源的 MKs 的结构特征和生物学活性产生了浓厚的兴趣。本综述总结和分析了海参（MKT）来源的 MKs 的现代研究结果，特别关注对这些 MKs 的抗氧化、抗炎和适应原活性及其可能的保护作用机制的现有知识的分析。
