Azzi L, Carinci F, Gabaglio S, Cura F, Croveri F, Tettamanti L, Tagliabue A, Segato S
Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, Dental Clinic, Unit of Oral Pathology, Varese, Italy.
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
J Biol Regul Homeost Agents. 2017 Jan-Mar;31(1):257-262.
It has been a long time since the scientific community started to speculate upon the presence of Helicobacter pylori (HP) in periodontal pockets as an extra-gastric reservoir responsible for gastric relapses after eradication therapy. The aim of this study is to evaluate the presence of oral HP in a group of patients who underwent examination for gastric infection. Sixty patients were enrolled in the current study, subdivided into two groups: 30 patients with a positive result for HP gastric infection with C-Breath Test Urea examination, and 30 patients with a negative result for HP gastric infection. Crevicular fluid and salivary samples were collected in a sterile tube and then sent to the laboratory for evaluation. Specimens were processed to quantify the levels of HP and bacterial load by real time PCR technique. Even though there was no statistically significant difference among the two groups (A vs B) with regard to the total amount of HP in saliva or in periodontal tissues, this study demonstrates that the oral cavity is an extra-gastric reservoir of HP when it is affected by periodontal disease, and that periodontal disease is correlated to gastric HP infection.
自科学界开始推测牙周袋中存在幽门螺杆菌（HP）作为根除治疗后导致胃部复发的胃外储存库以来，已经过去了很长时间。本研究的目的是评估一组接受胃部感染检查的患者中口腔HP的存在情况。本研究招募了60名患者，分为两组：30名C-呼气试验尿素检查显示胃部HP感染呈阳性的患者，以及30名胃部HP感染呈阴性的患者。龈沟液和唾液样本收集在无菌试管中，然后送往实验室进行评估。通过实时PCR技术对样本进行处理，以量化HP水平和细菌载量。尽管两组（A组与B组）在唾液或牙周组织中HP总量方面没有统计学上的显著差异，但本研究表明，当口腔受到牙周疾病影响时，口腔是HP的胃外储存库，并且牙周疾病与胃部HP感染相关。
