Dellis Athanasios, Papatsoris Athanasios, Kalentzos Vasileios, Deliveliotis Charalambos, Skolarikos Andreas
2nd Department of Surgery, National and Kapodistrian University of Athens, Aretaieion Academic Hospital, Greece.
2nd Department of Urology, University of Athens, Sismanoglio General Hospital, Athens, Greece.
Int Braz J Urol. 2017 May-Jun;43(3):489-495. doi: 10.1590/S1677-5538.IBJU.2016.0451.
To examine the safety and efficacy of hyperbaric oxygen as the primary and sole treatment for severe radiation-induced haemorrhagic cystitis.
Hyperbaric oxygen was prospectively applied as primary treatment in 38 patients with severe radiation cystitis. Our primary endpoint was the incidence of complete and partial response to treatment, while the secondary endpoints included the duration of response, the correlation of treatment success-rate to the interval between the onset of haematuria and initiation of therapy, blood transfusion need and total radiation dose, the number of sessions to success, the avoidance of surgery and the overall survival.
All patients completed therapy without complications with a mean follow-up of 29.33 months. Median number of sessions needed was 33. Complete and partial response rate was 86.8% and 13.2%, respectively. All 33 patients with complete response received therapy within 6 months of the haematuria onset. One patient needed cystectomy, while 33 patients were alive at the end of follow-up.
Our study suggests the early primary use of hyperbaric oxygen for radiation-induced severe cystitis as an effective and safe treatment option.
探讨高压氧作为重度放射性出血性膀胱炎的主要及唯一治疗方法的安全性和有效性。
前瞻性地将高压氧作为38例重度放射性膀胱炎患者的主要治疗方法。我们的主要终点是治疗的完全缓解率和部分缓解率，次要终点包括缓解持续时间、治疗成功率与血尿发作至开始治疗的间隔、输血需求和总辐射剂量的相关性、成功所需的疗程数、避免手术以及总生存率。
所有患者均完成治疗，无并发症，平均随访29.33个月。所需疗程的中位数为33次。完全缓解率和部分缓解率分别为86.8%和13.2%。所有33例完全缓解的患者在血尿发作后6个月内接受了治疗。1例患者需要膀胱切除术，33例患者在随访结束时存活。
我们的研究表明，早期将高压氧作为放射性重度膀胱炎的主要治疗方法是一种有效且安全的治疗选择。
